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Cat.No. 2204 - STEARDA | C26H45NO3 | CAS No. 105955-10-0
Description: Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors
Alternative Names: N-Stearoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).

Technical Data

M. Wt 419.64
Formula C26H45NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 105955-10-0
PubChem ID 10025103

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 2.1 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 419.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 47.66 mL 238.3 mL 476.6 mL
0.25 mM 9.53 mL 47.66 mL 95.32 mL
0.5 mM 4.77 mL 23.83 mL 47.66 mL
2.5 mM 0.95 mL 4.77 mL 9.53 mL

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References are publications that support the biological activity of the product.

Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293

If you know of a relevant reference for STEARDA, please let us know.

Keywords: STEARDA, STEARDA supplier, Endogenous, lipid, active, vivo, Enhances, effects, endovanilloids, TRPV1, receptors, inhibitors, inhibits, 5-lipoxygenase, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Lipoxygenase, Oxidase, Oxygenases, Oxidases, 5-LOX, N-Stearoyldopamine, 2204, Tocris Bioscience

1 Citation for STEARDA

Citations are publications that use Tocris products. Selected citations for STEARDA include:

Arensdorf (2017) Sonic Hedgehog activates phospholipase A2 to enhance Smoothened ciliary translocation. Cell Rep 19 2074 PMID: 28591579

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Literature in this Area

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.