You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||2.1||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 419.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||47.66 mL||238.3 mL||476.6 mL|
|0.25 mM||9.53 mL||47.66 mL||95.32 mL|
|0.5 mM||4.77 mL||23.83 mL||47.66 mL|
|2.5 mM||0.95 mL||4.77 mL||9.53 mL|
References are publications that support the biological activity of the product.
Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099
De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293
If you know of a relevant reference for STEARDA, please let us know.
View Related Products by Target
Keywords: STEARDA, STEARDA supplier, Endogenous, lipid, active, vivo, Enhances, effects, endovanilloids, TRPV1, receptors, inhibitors, inhibits, 5-lipoxygenase, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Lipoxygenase, Oxidase, Oxygenases, Oxidases, 5-LOX, N-Stearoyldopamine, 2204, Tocris Bioscience
1 Citation for STEARDA
Citations are publications that use Tocris products. Selected citations for STEARDA include:
Arensdorf (2017) Sonic Hedgehog activates phospholipase A2 to enhance Smoothened ciliary translocation. Cell Rep 19 2074 PMID: 28591579
Do you know of a great paper that uses STEARDA from Tocris? Please let us know.
Reviews for STEARDA
There are currently no reviews for this product. Be the first to review STEARDA and earn rewards!
Have you used STEARDA?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.