SR 8278

Pricing Availability Delivery Time Qty
Cat.No. 4463 - SR 8278 | C18H19NO3S2 | CAS No. 1254944-66-5
Description: Rev-Erbα antagonist
Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

Technical Data

M. Wt 361.48
Formula C18H19NO3S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1254944-66-5
PubChem ID 53393127
InChI Key UIEBLUZPSFAFOC-UHFFFAOYSA-N
Smiles CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.15 100
ethanol 18.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 361.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.66 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 6 131 PMID: 21043485


If you know of a relevant reference for SR 8278, please let us know.

View Related Products by Target

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View all Rev-Erb Receptor Antagonists

Keywords: SR 8278, SR 8278 supplier, SR8278, REV-ERB, heme, nuclear, receptors, antagonists, inhibits, glucose, regulation, Rev-Erb, Receptors, 4463, Tocris Bioscience

1 Citation for SR 8278

Citations are publications that use Tocris products. Selected citations for SR 8278 include:

Parker et al (2017) Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell 168 527 PMID: 28111073


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Literature in this Area

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