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Biological Activity for SR 8278
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
Compound Libraries for SR 8278
Technical Data for SR 8278
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 8278
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SR 8278
The following data is based on the product molecular weight 361.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.83 mL||27.66 mL|
|5 mM||0.55 mL||2.77 mL||5.53 mL|
|10 mM||0.28 mL||1.38 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References for SR 8278
References are publications that support the biological activity of the product.
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 6 131 PMID: 21043485
If you know of a relevant reference for SR 8278, please let us know.
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Keywords: SR 8278, SR 8278 supplier, SR8278, REV-ERB, heme, nuclear, receptors, antagonists, inhibits, glucose, regulation, Rev-Erb, Receptors, 4463, Tocris Bioscience
4 Citations for SR 8278
Citations are publications that use Tocris products. Selected citations for SR 8278 include:
Parker et al (2017) Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell 168 527 PMID: 28111073
Hyun Ok et al (2022) Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model. Biomol Ther (Seoul) 30 409-417 PMID: 35611585
Hanne M et al (2022) Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia. Sci Rep 12 17856 PMID: 36284122
Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687
Do you know of a great paper that uses SR 8278 from Tocris? Please let us know.
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