GSK 4112

Pricing Availability Delivery Time Qty
Cat.No. 3663 - GSK 4112 | C18H21ClN2O4S | CAS No. 1216744-19-2
Description: Selective Rev-Erbα agonist
Alternative Names: SR 6452
Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.

Technical Data

M. Wt 396.89
Formula C18H21ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1216744-19-2
PubChem ID 50905018
InChI Key WYSLOKHVFKLWOU-UHFFFAOYSA-N
Smiles CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.92 25

Preparing Stock Solutions

The following data is based on the product molecular weight 396.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.6 mL 25.2 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Meng et al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629 PMID:

Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131 PMID: 21043485


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View all Rev-Erb Receptor Agonists

Keywords: GSK4112 REV-ERBA REV-ERBα REV-ERBalpha agonists circadian rhythms SR6452 SR 6452 Rev-Erb Receptors

Citations for GSK 4112

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Nuclear Receptors

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Pathways for GSK 4112

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