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Biological Activity for GSK 4112
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
Compound Libraries for GSK 4112
Technical Data for GSK 4112
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 4112
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GSK 4112
The following data is based on the product molecular weight 396.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.08 mL||50.39 mL||100.78 mL|
|1.25 mM||2.02 mL||10.08 mL||20.16 mL|
|2.5 mM||1.01 mL||5.04 mL||10.08 mL|
|12.5 mM||0.2 mL||1.01 mL||2.02 mL|
References for GSK 4112
References are publications that support the biological activity of the product.
Meng et al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629 PMID: 18946026
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131 PMID: 21043485
If you know of a relevant reference for GSK 4112, please let us know.
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Keywords: GSK 4112, GSK 4112 supplier, GSK4112, REV-ERBA, REV-ERBα, REV-ERBalpha, agonists, circadian, rhythms, SR6452, SR, 6452, Rev-Erb, Receptors, 3663, Tocris Bioscience
1 Citation for GSK 4112
Citations are publications that use Tocris products. Selected citations for GSK 4112 include:
Chandra et al (2015) NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy. Autophagy 11 1987 PMID: 26390081
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Literature in this Area
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