Selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 396.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.52 mL||12.6 mL||25.2 mL|
|5 mM||0.5 mL||2.52 mL||5.04 mL|
|10 mM||0.25 mL||1.26 mL||2.52 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Meng et al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131 PMID: 21043485
If you know of a relevant reference for GSK 4112, please let us know.
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Keywords: GSK 4112, GSK 4112 supplier, GSK4112, REV-ERBA, REV-ERBα, REV-ERBalpha, agonists, circadian, rhythms, SR6452, SR, 6452, Rev-Erb, Receptors, 3663, Tocris Bioscience
1 Citation for GSK 4112
Citations are publications that use Tocris products. Selected citations for GSK 4112 include:
Chandra et al (2015) NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy. Autophagy 11 1987 PMID: 26390081
Do you know of a great paper that uses GSK 4112 from Tocris? Please let us know.
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Literature in this Area
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