SR 3029

Pricing Availability   Qty
Cat.No. 5767 - SR 3029 | C23H19F3N8O | CAS No. 1454585-06-8
Description: Potent and selective CK1δ and CK1ε inhibitor
Chemical Name: N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.

Technical Data

M. Wt 480.45
Formula C23H19F3N8O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1454585-06-8
PubChem ID 60196195
InChI Key CEBMEQPREMCWOL-UHFFFAOYSA-N
Smiles FC1=C(F)C2=C(N=C(CNC3=C4C(N(C5=CC=CC(F)=C5)C=N4)=NC(N6CCOCC6)=N3)N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.61 20

Preparing Stock Solutions

The following data is based on the product molecular weight 480.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.41 mL 52.03 mL 104.07 mL
1 mM 2.08 mL 10.41 mL 20.81 mL
2 mM 1.04 mL 5.2 mL 10.41 mL
10 mM 0.21 mL 1.04 mL 2.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Bibian et al (2013) Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg.Med.Chem.Lett. 23 4374 PMID: 23787102

Rosenberg et al (2015) Therapeutic targeting of casein kinase 1δ in breast cancer. Sci.Transl.Med. 7 318 PMID: 26676609


If you know of a relevant reference for SR 3029, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Casein Kinase 1 Inhibitors

Keywords: SR 3029, SR 3029 supplier, SR3029, CK1d, CK1e, δ, delta, ε, epsilon, casein, kinase, inhibitors, inhibits, potent, selective, Casein, Kinase, 1, 5767, Tocris Bioscience

Citations for SR 3029

Citations are publications that use Tocris products.

Currently there are no citations for SR 3029. Do you know of a great paper that uses SR 3029 from Tocris? Please let us know.

Reviews for SR 3029

There are currently no reviews for this product. Be the first to review SR 3029 and earn rewards!

Have you used SR 3029?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease