Potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 480.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.41 mL||52.03 mL||104.07 mL|
|1 mM||2.08 mL||10.41 mL||20.81 mL|
|2 mM||1.04 mL||5.2 mL||10.41 mL|
|10 mM||0.21 mL||1.04 mL||2.08 mL|
References are publications that support the biological activity of the product.
Bibian et al (2013) Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg.Med.Chem.Lett. 23 4374 PMID: 23787102
Rosenberg et al (2015) Therapeutic targeting of casein kinase 1δ in breast cancer. Sci.Transl.Med. 7 318 PMID: 26676609
If you know of a relevant reference for SR 3029, please let us know.
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Keywords: SR 3029, SR 3029 supplier, SR3029, CK1d, CK1e, δ, delta, ε, epsilon, casein, kinase, inhibitors, inhibits, potent, selective, Casein, Kinase, 1, 5767, Tocris Bioscience
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