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Submit ReviewSR 3029
Description: Potent and selective CK1δ and CK1ε inhibitor
Chemical Name: N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
Purity: ≥98% (HPLC)
Biological Activity for SR 3029
SR 3029 is a potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.
Technical Data for SR 3029
| M. Wt | 480.45 |
| Formula | C23H19F3N8O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1454585-06-8 |
| PubChem ID | 60196195 |
| InChI Key | CEBMEQPREMCWOL-UHFFFAOYSA-N |
| Smiles | FC1=C(F)C2=C(N=C(CNC3=C4C(N(C5=CC=CC(F)=C5)C=N4)=NC(N6CCOCC6)=N3)N2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SR 3029
References for SR 3029
References are publications that support the biological activity of the product.
Bibian et al (2013) Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg.Med.Chem.Lett. 23 4374 PMID: 23787102
Rosenberg et al (2015) Therapeutic targeting of casein kinase 1δ in breast cancer. Sci.Transl.Med. 7 318 PMID: 26676609
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Keywords: SR 3029, SR 3029 supplier, SR3029, CK1d, CK1e, δ, delta, ε, epsilon, casein, kinase, inhibitors, inhibits, potent, selective, Casein, Kinase, 1, 5767, Tocris Bioscience
Citations for SR 3029
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Cell Cycle and DNA Damage Research Product Guide
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