SR 3029

Pricing Availability   Qty
Description: Potent and selective CK1δ and CK1ε inhibitor
Chemical Name: N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for SR 3029

SR 3029 is a potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.

Technical Data for SR 3029

M. Wt 480.45
Formula C23H19F3N8O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1454585-06-8
PubChem ID 60196195
Smiles FC1=C(F)C2=C(N=C(CNC3=C4C(N(C5=CC=CC(F)=C5)C=N4)=NC(N6CCOCC6)=N3)N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 3029

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.61 20

Preparing Stock Solutions for SR 3029

The following data is based on the product molecular weight 480.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.41 mL 52.03 mL 104.07 mL
1 mM 2.08 mL 10.41 mL 20.81 mL
2 mM 1.04 mL 5.2 mL 10.41 mL
10 mM 0.21 mL 1.04 mL 2.08 mL

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References for SR 3029

References are publications that support the biological activity of the product.

Bibian et al (2013) Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg.Med.Chem.Lett. 23 4374 PMID: 23787102

Rosenberg et al (2015) Therapeutic targeting of casein kinase 1δ in breast cancer. Sci.Transl.Med. 7 318 PMID: 26676609

If you know of a relevant reference for SR 3029, please let us know.

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Citations for SR 3029

Citations are publications that use Tocris products.

Currently there are no citations for SR 3029. Do you know of a great paper that uses SR 3029 from Tocris? Please let us know.

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