Spaglumic acid

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Cat.No. 0391 - Spaglumic acid | C11H16N2O8 | CAS No. 3106-85-2
Description: Selective mGlu3 agonist
Alternative Names: α-NAAG
Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid
Purity: ≥96% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.

Technical Data

M. Wt 304.26
Formula C11H16N2O8
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 3106-85-2
PubChem ID 188803
InChI Key OPVPGKGADVGKTG-BQBZGAKWSA-N
Smiles CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 304.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.87 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443 PMID: 10899918

Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16 PMID: 10991955

Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174 PMID: 9202308


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Keywords: Putative endogenous neurotransmitter Selective mGlu3 agonists Glutamate mGlur Receptors Metabotropic Group II iGluR Ionotropic alpha-NAAG NAAG a-NAAG Glutamate (Metabotropic) Group II Receptors

1 Citation for Spaglumic acid

Citations are publications that use Tocris products. Selected citations for Spaglumic acid include:

Kolodziejczyk et al (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain 132 1496 PMID: 19383832


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