The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 304.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.29 mL||16.43 mL||32.87 mL|
|5 mM||0.66 mL||3.29 mL||6.57 mL|
|10 mM||0.33 mL||1.64 mL||3.29 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443 PMID: 10899918
Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16 PMID: 10991955
Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174 PMID: 9202308
If you know of a relevant reference for Spaglumic acid, please let us know.
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Keywords: Putative endogenous neurotransmitter Selective mGlu3 agonists Glutamate mGlur Receptors Metabotropic Group II iGluR Ionotropic alpha-NAAG NAAG a-NAAG Glutamate (Metabotropic) Group II Receptors
1 Citation for Spaglumic acid
Citations are publications that use Tocris products. Selected citations for Spaglumic acid include:
Kolodziejczyk et al (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain 132 1496 PMID: 19383832
Do you know of a great paper that uses Spaglumic acid from Tocris? If so please let us know.
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