Sonepiprazole

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Cat.No. 4185 - Sonepiprazole | C21H27N3O3S | CAS No. 170858-33-0
Description: Selective D4 antagonist
Alternative Names: PNU 101387, U 101387
Chemical Name: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective, high affinity antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM). Exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 401.52
Formula C21H27N3O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 170858-33-0
PubChem ID 133079
InChI Key WNUQCGWXPNGORO-NRFANRHFSA-N
Smiles O=S(C1=CC=C(N2CCN(CC[C@H]3C(C=CC=C4)=C4CCO3)CC2)C=C1)(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 401.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Merchant et al (1996) Pharmacological characterization of U-101387, a DA D4 receptor selective antagonist. J.Pharm.Exp.Ther. 279 1392


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