SNS 314 mesylate

Pricing Availability   Qty
Description: Potent pan-Aurora kinase inhibitor
Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for SNS 314 mesylate

SNS 314 mesylate is a potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).

Technical Data for SNS 314 mesylate

M. Wt 527.04
Formula C18H15ClN6OS2.CH3SO3H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1146618-41-8
PubChem ID 24995523
Smiles O=C(NC4=CC(Cl)=CC=C4)NC3=NC=C(S3)CCNC1=NC=NC2=C1SC=C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNS 314 mesylate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.7 100

Preparing Stock Solutions for SNS 314 mesylate

The following data is based on the product molecular weight 527.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.49 mL 18.97 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for SNS 314 mesylate

References for SNS 314 mesylate

References are publications that support the biological activity of the product.

Arbitrario et al (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo. Cancer Chemother. Pharmacol. 65 707 PMID: 19649632

VanderPorten et al (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol.Cancer Ther. 8 930 PMID: 19372566

Oslob et al (2008) Discovery of a potent and selective Aurora kinase inhibitor. Bioorg.Med.Chem.Lett. 18 4880 PMID: 18678489

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