SN 2
Biological Activity
Selective TRPML3 channel activator (EC50 = 1.13 μM).
Compound Libraries
SN 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 255.35 |
| Formula | C17H21NO |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 823218-99-1 |
| PubChem ID | 11834987 |
| InChI Key | WKLZNTYMDOPBSE-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 25.53 | 100 | |
| DMSO | 25.53 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 255.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.92 mL | 19.58 mL | 39.16 mL |
| 5 mM | 0.78 mL | 3.92 mL | 7.83 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Grimm et al (2010) Small molecule activators of TRPML3. Chem.Biol. 17 135 PMID: 20189104
Jörs (2010) Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS ONE 5 e14317 PMID: 21179200
If you know of a relevant reference for SN 2, please let us know.
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Keywords: SN 2, supplier, Selective, TRPML3, channels, activators, SN2, transient, receptor, potential, channels, activates, TRPML, TRPML, Tocris Bioscience
Citations for SN 2
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Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
