SN 2

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Cat.No. 4907 - SN 2 | C17H21NO | CAS No. 823218-99-1
Description: Selective TRPML3 channel activator
Chemical Name: 3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for SN 2

SN 2 is a selective TRPML3 channel activator (EC50 = 1.13 μM).

Compound Libraries for SN 2

SN 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SN 2

M. Wt 255.35
Formula C17H21NO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 823218-99-1
PubChem ID 11834987
Smiles CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SN 2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.53 100
ethanol 25.53 100

Preparing Stock Solutions for SN 2

The following data is based on the product molecular weight 255.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.16 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References for SN 2

References are publications that support the biological activity of the product.

Grimm et al (2010) Small molecule activators of TRPML3. Chem.Biol. 17 135 PMID: 20189104

Jörs (2010) Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS ONE 5 e14317 PMID: 21179200

If you know of a relevant reference for SN 2, please let us know.

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Citations for SN 2

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Autophagy Scientific Review

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.