SN 2

Pricing Availability   Qty
Cat.No. 4907 - SN 2 | C17H21NO | CAS No. 823218-99-1
Description: Selective TRPML3 channel activator
Chemical Name: 3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective TRPML3 channel activator (EC50 = 1.13 μM).

Compound Libraries

SN 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 255.35
Formula C17H21NO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 823218-99-1
PubChem ID 11834987
InChI Key WKLZNTYMDOPBSE-UHFFFAOYSA-N
Smiles CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 25.53 100
DMSO 25.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 255.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.16 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Grimm et al (2010) Small molecule activators of TRPML3. Chem.Biol. 17 135 PMID: 20189104

Jörs (2010) Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS ONE 5 e14317 PMID: 21179200


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Citations for SN 2

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Autophagy

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.