SN 2

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Cat.No. 4907 - SN 2 | C17H21NO | CAS No. 823218-99-1
Description: Selective TRPML3 channel activator
Chemical Name: 3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective TRPML3 channel activator (EC50 = 1.13 μM).

Compound Libraries

SN 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 255.35
Formula C17H21NO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 823218-99-1
PubChem ID 11834987
InChI Key WKLZNTYMDOPBSE-UHFFFAOYSA-N
Smiles CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.53 100
ethanol 25.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 255.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.16 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Grimm et al (2010) Small molecule activators of TRPML3. Chem.Biol. 17 135 PMID: 20189104

Jörs (2010) Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS ONE 5 e14317 PMID: 21179200


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Keywords: Selective TRPML3 channels activators SN2 transient receptor potential channels activates TRPML

Citations for SN 2

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Literature in this Area

Autophagy

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Pathways for SN 2

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