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Description: Selective TRPML3 channel activator
Chemical Name: 3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole
Purity: ≥98% (HPLC)
Biological Activity for SN 2
SN 2 is a selective TRPML3 channel activator (EC50 = 1.13 μM).
Compound Libraries for SN 2
SN 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SN 2
| M. Wt | 255.35 |
| Formula | C17H21NO |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 823218-99-1 |
| PubChem ID | 11834987 |
| InChI Key | WKLZNTYMDOPBSE-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SN 2
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.53 | 100 | |
| ethanol | 25.53 | 100 |
Preparing Stock Solutions for SN 2
The following data is based on the product molecular weight 255.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.92 mL | 19.58 mL | 39.16 mL |
| 5 mM | 0.78 mL | 3.92 mL | 7.83 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets for SN 2
References for SN 2
References are publications that support the biological activity of the product.
Grimm et al (2010) Small molecule activators of TRPML3. Chem.Biol. 17 135 PMID: 20189104
Jörs (2010) Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS ONE 5 e14317 PMID: 21179200
If you know of a relevant reference for SN 2, please let us know.
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Keywords: SN 2, SN 2 supplier, Selective, TRPML3, channels, activators, SN2, transient, receptor, potential, activates, TRPML, 4907, Tocris Bioscience
Citations for SN 2
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.