You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for SM-21 maleate
SM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.
Technical Data for SM-21 maleate
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SM-21 maleate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SM-21 maleate
The following data is based on the product molecular weight 453.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||8.81 mL||44.06 mL||88.12 mL|
|1.25 mM||1.76 mL||8.81 mL||17.62 mL|
|2.5 mM||0.88 mL||4.41 mL||8.81 mL|
|12.5 mM||0.18 mL||0.88 mL||1.76 mL|
References for SM-21 maleate
References are publications that support the biological activity of the product.
Ghelardini et al (1997) Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 282 430 PMID: 9223584
Ghelardini et al (2000) Pharmacological identification of SM-21, the novel σ2 antagonist. Pharmacol.Biochem.Behav. 67 659 PMID: 11164098
Matsumoto and Mack (2001) (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 417 R1 PMID: 11301071
If you know of a relevant reference for SM-21 maleate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SM-21 maleate, SM-21 maleate supplier, Selective, σ2, sigma2, receptors, antagonists, Presynaptic, cholinergic, modulators, Muscarinic, Acetylcholine, release, Nicotinic, nAChR, Other, Sigma2, Receptors, Non-selective, Muscarinics, 0751, Tocris Bioscience
3 Citations for SM-21 maleate
Citations are publications that use Tocris products. Selected citations for SM-21 maleate include:
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Ishima and Hashimoto (2012) Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of σ-1 and IP3 receptors. J Diabetes Res 7 e37989 PMID: 22655093
Matsumoto et al (2007) Effects of UMB24 and (+/-)-SM 21, putative σ2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice. PLoS One 86 86 PMID: 17241657
Do you know of a great paper that uses SM-21 maleate from Tocris? Please let us know.
Reviews for SM-21 maleate
There are currently no reviews for this product. Be the first to review SM-21 maleate and earn rewards!
Have you used SM-21 maleate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.