SKF 97541

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Cat.No. 0379 - SKF 97541 | C4H12NO2P | CAS No. 127729-35-5
Description: Extremely potent GABAB agonist
Alternative Names: CGP 35024
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Very potent GABAB agonist, at least ten times more active than baclofen (Cat. No. 0417). Also GABAA-ρ antagonist.

Technical Data

M. Wt 137.12
Formula C4H12NO2P
Storage Desiccate at RT
CAS Number 127729-35-5
PubChem ID 5230
InChI Key NHVRIDDXGZPJTJ-UHFFFAOYSA-N
Smiles NCCCP(O)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.71 100

Preparing Stock Solutions

The following data is based on the product molecular weight 137.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.29 mL 36.46 mL 72.93 mL
5 mM 1.46 mL 7.29 mL 14.59 mL
10 mM 0.73 mL 3.65 mL 7.29 mL
50 mM 0.15 mL 0.73 mL 1.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bon and Galvan (1996) Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 118 961 PMID: 8799569

Froestl et al (1995) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J.Med.Chem. 38 3297 PMID: 7650684

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Seabrook et al (1990) Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices. Br.J.Pharmacol. 101 949 PMID: 1964824


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Keywords: SKF 97541, supplier, potent, GABAB, agonists, GABAC, antagonists, Receptors, SKF97541, CGP35024, CGP, 35024, GABAB, Receptors, GABAA-rho, Receptors, GABAB, Receptors, Tocris Bioscience

6 Citations for SKF 97541

Citations are publications that use Tocris products. Selected citations for SKF 97541 include:

Lecat-Guillet (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Mol Pain 131 1050 PMID: 11082110

Ignell et al (2009) Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila. Br J Pharmacol 106 13070 PMID: 19625621

Root et al (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59 311 PMID: 18667158

Chen et al (2008) Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice. Mol Pain 4 41 PMID: 18826595

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585


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