SKF 97541

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Description: Highly potent GABAB agonist; also GABAA-ρ antagonist
Alternative Names: CGP 35024
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid
Citations (8)
Reviews (1)
Literature (2)

Biological Activity for SKF 97541

SKF 97541 is a potent GABAB agonist (EC50 = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC50 values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABAA-ρ antagonist.

Technical Data for SKF 97541

M. Wt 137.12
Formula C4H12NO2P
Storage Desiccate at RT
CAS Number 127729-35-5
PubChem ID 5230
Smiles NCCCP(O)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SKF 97541

Solvent Max Conc. mg/mL Max Conc. mM
water 13.71 100

Preparing Stock Solutions for SKF 97541

The following data is based on the product molecular weight 137.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.29 mL 36.46 mL 72.93 mL
5 mM 1.46 mL 7.29 mL 14.59 mL
10 mM 0.73 mL 3.65 mL 7.29 mL
50 mM 0.15 mL 0.73 mL 1.46 mL

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Product Datasheets for SKF 97541

Certificate of Analysis / Product Datasheet
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References for SKF 97541

References are publications that support the biological activity of the product.

Bon and Galvan (1996) Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 118 961 PMID: 8799569

Froestl et al (1995) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J.Med.Chem. 38 3297 PMID: 7650684

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Seabrook et al (1990) Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices. Br.J.Pharmacol. 101 949 PMID: 1964824

If you know of a relevant reference for SKF 97541, please let us know.

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Keywords: SKF 97541, SKF 97541 supplier, potent, GABAB, agonists, GABAC, antagonists, Receptors, SKF97541, CGP35024, CGP, 35024, GABAA-rho, 0379, Tocris Bioscience

8 Citations for SKF 97541

Citations are publications that use Tocris products. Selected citations for SKF 97541 include:

Ignell et al (2009) Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila. Br J Pharmacol 106 13070 PMID: 19625621

Root et al (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59 311 PMID: 18667158

Chen et al (2008) Differential regulation of mor. antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice. Mol Pain 4 41 PMID: 18826595

Ki and Lim (2019) Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. Elife 8 PMID: 31313987

Do you know of a great paper that uses SKF 97541 from Tocris? Please let us know.

Reviews for SKF 97541

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Test of potential modulation of 5HT-1B receptor effects.
By Sergiy Sylantyev on 12/10/2023
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Arcuate nucleus

SKF 97541 was used to test a (potential) impact of GABA-B receptors on the effect of 5HT-1B receptors on neurotransmitter vesicle release in interneuronal synapse. Picture: membrane capacitance fluctuation of living neuron after series of electrical stimuli delivered to acute neural tissue. Left: control. Right: activation of GABA-B receptors (with 1 microM SKF 97541), mGlu receptors and ACh receptors do not show a significant effect. Grey traces: individual recordings; red: averaged trace.

PMID: 37827445
review image

Literature in this Area

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GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.