SKF 97541

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Description: Highly potent GABAB agonist; also GABAA-ρ antagonist
Alternative Names: CGP 35024
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid
Citations (8)
Literature (6)

Biological Activity for SKF 97541

SKF 97541 is a potent GABAB agonist (EC50 = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC50 values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABAA-ρ antagonist.

Technical Data for SKF 97541

M. Wt 137.12
Formula C4H12NO2P
Storage Desiccate at RT
CAS Number 127729-35-5
PubChem ID 5230
Smiles NCCCP(O)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SKF 97541

Solvent Max Conc. mg/mL Max Conc. mM
water 13.71 100

Preparing Stock Solutions for SKF 97541

The following data is based on the product molecular weight 137.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.29 mL 36.46 mL 72.93 mL
5 mM 1.46 mL 7.29 mL 14.59 mL
10 mM 0.73 mL 3.65 mL 7.29 mL
50 mM 0.15 mL 0.73 mL 1.46 mL

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Product Datasheets for SKF 97541

Certificate of Analysis / Product Datasheet
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References for SKF 97541

References are publications that support the biological activity of the product.

Bon and Galvan (1996) Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 118 961 PMID: 8799569

Froestl et al (1995) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J.Med.Chem. 38 3297 PMID: 7650684

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Seabrook et al (1990) Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices. Br.J.Pharmacol. 101 949 PMID: 1964824

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Keywords: SKF 97541, SKF 97541 supplier, potent, GABAB, agonists, GABAC, antagonists, Receptors, SKF97541, CGP35024, CGP, 35024, GABAA-rho, 0379, Tocris Bioscience

8 Citations for SKF 97541

Citations are publications that use Tocris products. Selected citations for SKF 97541 include:

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585

Martelli and Fiala (2019) Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. Elife 8 PMID: 31169499

Lecat-Guillet (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129

Ki and Lim (2019) Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. Elife 8 PMID: 31313987

Do you know of a great paper that uses SKF 97541 from Tocris? Please let us know.

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Literature in this Area

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