SKF 83822 hydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 2075 - SKF 83822 hydrobromide | C20H22ClNO2.HBr | CAS No. 74115-10-9
Description: Selective D1-like agonist
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.

Technical Data

M. Wt 424.76
Formula C20H22ClNO2.HBr
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 74115-10-9
PubChem ID 12909789
InChI Key CFWPKYBBXBANLU-UHFFFAOYSA-N
Smiles ClC1=C(O)C(O)=CC2=C1CCN(CC=C)CC2C3=CC=CC(C)=C3.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.38 100
ethanol 3.44 10

Preparing Stock Solutions

The following data is based on the product molecular weight 424.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.77 mL 23.54 mL
5 mM 0.47 mL 2.35 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Undie et al (1994) Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J.Neurochem. 62 2045 PMID: 7908949

Peacock and Gerlach (2001) Aberrant behavioural effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol.Psychiatry 50 501 PMID: 11600103

O'Sullivan et al (2004) SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography. Eur.J.Pharmacol. 486 273 PMID: 14985049


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Keywords: Selective D1-like agonists Dopamine D1 Receptors D5 dopaminergic SKF83822 hydrobromide D1 and D5 Receptors

3 Citations for SKF 83822 hydrobromide

Citations are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:

Kramar et al (2014) Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. J Neurosci 39 1645 PMID: 24442095

Ruskin et al (2013) Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One 8 e65021 PMID: 23755170

Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Neuropsychopharmacology 7 624 PMID: 21785426


Do you know of a great paper that uses SKF 83822 hydrobromide from Tocris? If so please let us know.

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