SKF 82958 hydrobromide

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Cat.No. 5719 - SKF 82958 hydrobromide | C19H20ClNO2.HBr | CAS No. 74115-01-8
Description: D1 agonist
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol hydrobromide
Purity: ≥98% (HPLC)

Biological Activity

D1 agonist. Increases renal blood flow in animal models and promotes contralateral rotation in rats with unilateral lesions of the substantia nigra. Also augments GABAB inhibitory post-synaptic potentials (ipsp) in ventral tegmental area in brain slices.

Technical Data

M. Wt 410.73
Formula C19H20ClNO2.HBr
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 74115-01-8
PubChem ID 9909521
Smiles OC1=CC(C(C2=CC=CC=C2)CN(CC=C)CC3)=C3C(Cl)=C1O.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.07 100
water 2.05 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 410.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.17 mL 24.35 mL
5 mM 0.49 mL 2.43 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References are publications that support the products' biological activity.

Pfeiffer et al (1982) Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. J.Med.Chem. 25 352 PMID: 7069713

Cameron and Williams (1993) Dopamine D1 receptors facilitate transmitter release. Nature 366 344 PMID: 8247128

If you know of a relevant reference for SKF 82958 hydrobromide, please let us know.

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