SKF 77434 hydrobromide

Discontinued Product

SKF 77434 hydrobromide (Cat. No. 1662) has been withdrawn from sale for commercial reasons.
Description: Selective D1-like partial agonist
Chemical Name: 2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity for SKF 77434 hydrobromide

SKF 77434 hydrobromide is a selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SKF 77434 hydrobromide

M. Wt 376.29
Formula C19H21NO2.HBr
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 300561-58-4
PubChem ID 11957703
Smiles Br.OC1=CC2=C(C=C1O)C(CN(CC=C)CC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SKF 77434 hydrobromide

Certificate of Analysis / Product Datasheet
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References for SKF 77434 hydrobromide

References are publications that support the biological activity of the product.

Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038 PMID: 1687364

Meyer and Schults (1993) DA D1 receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats. Pharmacol.Biochem.Behav. 46 269 PMID: 7903456

Neumeyer et al (1992) Stereoisomeric probes for the D1 DA receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. J.Med.Chem. 35 1466 PMID: 1533424

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Keywords: SKF 77434 hydrobromide, SKF 77434 hydrobromide supplier, Selective, D1-like, partial, agonists, Dopamine, Receptors, D5, dopaminergic, SKF77434, hydrobromide, GlaxoSmithKline, GSK, D1, and, 1662, Tocris Bioscience

Citations for SKF 77434 hydrobromide

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Currently there are no citations for SKF 77434 hydrobromide.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.