SKF 77434 hydrobromide

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Cat.No. 1662 - SKF 77434 hydrobromide | C19H21NO2.HBr | CAS No. 300561-58-4
Description: Selective D1-like partial agonist
Chemical Name: 2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 376.29
Formula C19H21NO2.HBr
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 300561-58-4
PubChem ID 11957703
InChI Key JWQRAXTWDYUBFI-UHFFFAOYSA-N
Smiles Br.OC1=CC2=C(C=C1O)C(CN(CC=C)CC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.54 100
ethanol 2.95 10
water 3.76 10

Preparing Stock Solutions

The following data is based on the product molecular weight 376.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.29 mL 26.58 mL
5 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038 PMID: 1687364

Meyer and Schults (1993) Dopamine D1 receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats. Pharmacol.Biochem.Behav. 46 269 PMID: 7903456

Neumeyer et al (1992) Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. J.Med.Chem. 35 1466 PMID: 1533424


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Keywords: Selective D1-like partial agonists Dopamine Receptors D5 dopaminergic SKF77434 hydrobromide GlaxoSmithKline GSK D1 and D5 Receptors

Citations for SKF 77434 hydrobromide

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