SIB 1757

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Cat.No. 1215 - SIB 1757 | C12H11N3O | CAS No. 31993-01-8
Description: Highly selective mGlu5 antagonist
Chemical Name: 6-Methyl-2-(phenylazo)-3-pyridinol
Datasheet
Citations (1)
Literature

Biological Activity

A highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype; displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.

Technical Data

M. Wt 213.24
Formula C12H11N3O
Storage Store at RT
CAS Number 31993-01-8
PubChem ID 5311432
InChI Key SISOFUCTXZKSOQ-ZHACJKMWSA-N
Smiles CC1=NC(\N=N\C2=CC=CC=C2)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 213.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.69 mL 23.45 mL 46.9 mL
5 mM 0.94 mL 4.69 mL 9.38 mL
10 mM 0.47 mL 2.34 mL 4.69 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Varney et al (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 290 170 PMID: 10381773

Varney et al (1999) Characterisation of SIB-1757 and SIB-1893: highly selective antagonists at metabotropic glutamate receptor subtype 5. Br.J.Pharmacol. 126 248P PMID:


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View all Glutamate (Metabotropic) Group I Receptor Antagonists

Keywords: selective mGlu5 mGluR5 antagonist Group I Receptors Glutamate Metabotropic SIB1757 Glutamate (Metabotropic) Group I Receptors

1 Citation for SIB 1757

Citations are publications that use Tocris products. Selected citations for SIB 1757 include:

El-Kouhen et al (2006) Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol 149 761 PMID: 17016515


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Pathways for SIB 1757

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