SIB 1508Y maleate

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Cat.No. 4766 - SIB 1508Y maleate | C12H14N2.C4H4O4 | CAS No. 192231-16-6
Description: Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors
Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Technical Data

M. Wt 302.33
Formula C12H14N2.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 192231-16-6
PubChem ID 10968648
InChI Key BCPPKHPWLRPWBJ-OURKGEEVSA-N
Smiles CN1CCC[C@H]1[C@]2=CC(C#C)=CN=C2.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.12 50
water 30.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 302.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.08 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cosford et al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235 PMID: 8765504

Schneider et al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731 PMID: 10411585


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Keywords: SIB1508Y maleate potent neuronal nicotinic acetylcholine nACHRs receptors alpha3beta4 alpha2beta4 alpha4beta4 alpha4beta2 a3b4 a2b4 a4b4 a4b2 Parkinson's Disease ligand-gated ion channels Nicotinic Receptors (Non-selective)

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Literature in this Area

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Pathways for SIB 1508Y maleate

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