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SIB 1508Y maleate

Cat. No. 4766 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors
Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SIB 1508Y maleate

SIB 1508Y maleate is a potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Technical Data for SIB 1508Y maleate

M. Wt 302.33
Formula C12H14N2.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 192231-16-6
PubChem ID 10968648
InChI Key BCPPKHPWLRPWBJ-OURKGEEVSA-N
Smiles CN1CCC[C@H]1[C@]2=CC(C#C)=CN=C2.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SIB 1508Y maleate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.23 100
DMSO 15.12 50

Preparing Stock Solutions for SIB 1508Y maleate

The following data is based on the product molecular weight 302.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.08 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for SIB 1508Y maleate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for SIB 1508Y maleate

References are publications that support the biological activity of the product.

Cosford et al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235 PMID: 8765504

Schneider et al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731 PMID: 10411585

If you know of a relevant reference for SIB 1508Y maleate, please let us know.

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Keywords: SIB 1508Y maleate, SIB 1508Y maleate supplier, SIB1508Y, maleate, potent, neuronal, nicotinic, acetylcholine, nACHRs, receptors, alpha3beta4, alpha2beta4, alpha4beta4, alpha4beta2, a3b4, a2b4, a4b4, a4b2, Parkinson's, Disease, ligand-gated, ion, channels, Nicotinic, Receptors, (Non-selective), (a4b2), (Other, Subtypes), 4766, Tocris Bioscience

Citations for SIB 1508Y maleate

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Literature in this Area

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