SIB 1508Y maleate

Discontinued Product

SIB 1508Y maleate (Cat. No. 4766) has been withdrawn from sale for commercial reasons.
Description: Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors
Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for SIB 1508Y maleate

SIB 1508Y maleate is a potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Technical Data for SIB 1508Y maleate

M. Wt 302.33
Formula C12H14N2.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 192231-16-6
PubChem ID 10968648
InChI Key BCPPKHPWLRPWBJ-OURKGEEVSA-N
Smiles CN1CCC[C@H]1[C@]2=CC(C#C)=CN=C2.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SIB 1508Y maleate

References for SIB 1508Y maleate

References are publications that support the biological activity of the product.

Cosford et al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235 PMID: 8765504

Schneider et al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731 PMID: 10411585

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Keywords: SIB 1508Y maleate, SIB 1508Y maleate supplier, SIB1508Y, maleate, potent, neuronal, nicotinic, acetylcholine, nACHRs, receptors, alpha3beta4, alpha2beta4, alpha4beta4, alpha4beta2, a3b4, a2b4, a4b4, a4b2, Parkinson's, Disease, ligand-gated, ion, channels, Nicotinic, Receptors, (Non-selective), (a4b2), (Other, Subtypes), 4766, Tocris Bioscience

Citations for SIB 1508Y maleate

Citations are publications that use Tocris products.

Currently there are no citations for SIB 1508Y maleate.

Reviews for SIB 1508Y maleate

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.