ShK-Dap22

Discontinued Product

ShK-Dap22 (Cat. No. 3220) has been withdrawn from sale for commercial reasons.
Description: Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews (1)

Biological Activity for ShK-Dap22

ShK-Dap22 is an extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).

Technical Data for ShK-Dap22

M. Wt 4012.7
Formula C166H268N54O48S7
Sequence RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC

(Modifications: Disulfide bridges: 3-35, 12-28, 17-32, X= Dap)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 220384-25-8
PubChem ID 122187345
InChI Key PFWOJTLVNOZSGQ-RIMJLNMDSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ShK-Dap22

Certificate of Analysis / Product Datasheet
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References for ShK-Dap22

References are publications that support the biological activity of the product.

Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 273 32697 PMID: 9830012

Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID: 15677684

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Keywords: ShK-Dap22, ShK-Dap22 supplier, toxins, potassium, channels, Kv1.3, potent, selective, blockers, inhibitors, inhibits, immunosuppressives, T, cells, venoms, Voltage-Gated, Potassium, Channels, 3220, Tocris Bioscience

Citations for ShK-Dap22

Citations are publications that use Tocris products.

Currently there are no citations for ShK-Dap22.

Reviews for ShK-Dap22

Average Rating: 5 (Based on 1 Review.)

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Great product with reproducible data.
By Sadequl Islam on 10/22/2018
Assay Type: In Vitro
Species: Human

This compound was used in our cell culture lab to quantify blocking activity of Kv channels. It produced reproducible data in osteosarcoma cell line. Great product, hugely recommend.

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