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Submit ReviewShK-Dap22
Description: Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
Purity: ≥95% (HPLC)
Biological Activity for ShK-Dap22
ShK-Dap22 is an extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).
Technical Data for ShK-Dap22
| M. Wt | 4012.7 |
| Formula | C166H268N54O48S7 |
| Sequence |
RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC (Modifications: Disulfide bridges: 3-35, 12-28, 17-32, X= Dap) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 220384-25-8 |
| PubChem ID | 122187345 |
| InChI Key | PFWOJTLVNOZSGQ-RIMJLNMDSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ShK-Dap22
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for ShK-Dap22
References for ShK-Dap22
References are publications that support the biological activity of the product.
Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 273 32697 PMID: 9830012
Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID: 15677684
If you know of a relevant reference for ShK-Dap22, please let us know.
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Keywords: ShK-Dap22, ShK-Dap22 supplier, toxins, potassium, channels, Kv1.3, potent, selective, blockers, inhibitors, inhibits, immunosuppressives, T, cells, venoms, Voltage-Gated, Potassium, Channels, 3220, Tocris Bioscience
Citations for ShK-Dap22
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Reviews for ShK-Dap22
Average Rating: 5 (Based on 1 Review.)
Have you used ShK-Dap22?
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Great product with reproducible data.
By
Sadequl Islam on 10/22/2018
Assay Type: In Vitro
Species: Human
This compound was used in our cell culture lab to quantify blocking activity of Kv channels. It produced reproducible data in osteosarcoma cell line. Great product, hugely recommend.
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Ion Channel Product Listing
A collection of around 500 products for ion channel research, the listing includes research tools for the study of:
- Ligand-gated ion channels
- Voltage-gated ion channels
- Other Ion Channels