SF 1670

Pricing Availability Delivery Time Qty
Cat.No. 5020 - SF 1670 | C19H17NO3 | CAS No. 345630-40-2
Description: PTEN inhibitor
Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Purity: ≥98% (HPLC)

Biological Activity

PTEN inhibitor. Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice.

Technical Data

M. Wt 307.34
Formula C19H17NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 345630-40-2
PubChem ID 9926586
Smiles O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 307.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702 PMID: 21521784

If you know of a relevant reference for SF 1670, please let us know.

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Keywords: SF1670 PTEN inhibitors phosphatase tensin homolog deleted chromosome 10 neutrophils transfusion inhibits Protein Tyrosine Phosphatases

Citations for SF 1670

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for SF 1670


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