SF 1670

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Cat.No. 5020 - SF 1670 | C19H17NO3 | CAS No. 345630-40-2
Description: PTPN2 and PTEN inhibitor
Alternative Names: PTP Inhibitor XIX
Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Technical Data

M. Wt 307.34
Formula C19H17NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 345630-40-2
PubChem ID 9926586
InChI Key VZQDDSYKVYARDW-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 307.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702 PMID: 21521784

Le et al (2017) Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 0 329 PMID: 8228214


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Citations for SF 1670

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