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Submit ReviewSF 1670
Description: PTPN2 and PTEN inhibitor
Alternative Names: PTP Inhibitor XIX
Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Purity: ≥98% (HPLC)
Biological Activity for SF 1670
SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.
Technical Data for SF 1670
| M. Wt | 307.34 |
| Formula | C19H17NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 345630-40-2 |
| PubChem ID | 9926586 |
| InChI Key | VZQDDSYKVYARDW-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SF 1670
References for SF 1670
References are publications that support the biological activity of the product.
Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702 PMID: 21521784
Le et al (2017) Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 50 329 PMID: 28228214
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Keywords: SF 1670, SF 1670 supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, PTPN2, CD45, cancer, immunotherapy, PTP, Inhibitor, XIX, Protein, Tyrosine, Phosphatases, 5020, Tocris Bioscience
2 Citations for SF 1670
Citations are publications that use Tocris products. Selected citations for SF 1670 include:
Gail A et al (2022) TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22. Sci Signal 15 eabn5507 PMID: 36166512
Lei et al (2017) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. J Cell Biol 216 2551 PMID: 28659327
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