SET 2

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Cat.No. 6990 - SET 2 | C17H21F3N4O2S | CAS No. 2313525-20-9
Description: Selective TRPV2 antagonist
Chemical Name: N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50 = 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migration in vitro.

Technical Data

M. Wt 402.44
Formula C17H21F3N4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2313525-20-9
InChI Key LZHSWRWIMQRTOP-UHFFFAOYSA-N
Smiles CCCN(C1=NC(SCCC(NCC2=CC=CO2)=O)=NC(C(F)(F)F)=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.24 100
ethanol 20.12 50

Preparing Stock Solutions

The following data is based on the product molecular weight 402.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.85 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Chai et al (2019) Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel. J.Med.Chem. 62 1373 PMID: 30620187


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Citations for SET 2

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