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Biological Activity for SET 2
SET 2 is a TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50 = 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migration in vitro.
Technical Data for SET 2
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SET 2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SET 2
The following data is based on the product molecular weight 402.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.48 mL||12.42 mL||24.85 mL|
|5 mM||0.5 mL||2.48 mL||4.97 mL|
|10 mM||0.25 mL||1.24 mL||2.48 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References for SET 2
References are publications that support the biological activity of the product.
Chai et al (2019) Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel. J.Med.Chem. 62 1373 PMID: 30620187
If you know of a relevant reference for SET 2, please let us know.
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Citations for SET 2
Citations are publications that use Tocris products.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.