Sertraline hydrochloride

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Cat.No. 2395 - Sertraline hydrochloride | C17H17Cl2N.HCl | CAS No. 79559-97-0
Description: 5-HT re-uptake inhibitor
Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent, orally active selective serotonin re-uptake inhibitor (SSRI); antidepressant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Sertraline hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 342.69
Formula C17H17Cl2N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 79559-97-0
PubChem ID 63009
InChI Key BLFQGGGGFNSJKA-XHXSRVRCSA-N
Smiles ClC(C(Cl)=C3)=CC=[C@@]3[C@H]2C1=CC=CC=C1[C@@H](NC)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.26 100
ethanol 17.13 50
water 1.71 5

Preparing Stock Solutions

The following data is based on the product molecular weight 342.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.59 mL 29.18 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Koe et al (1983) Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 226 686 PMID: 6310078

Heym and Koe (1988) Pharmacology of sertraline: a review. J.Clin.Psychiatry 49 40 PMID: 3045112

Doogan and Caillard (1988) Sertraline: a new antidepressant. J.Clin.Psychiatry. 49 46 PMID:


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Keywords: 5-HT reuptake inhibitors inhibits Serotonin Transporters SERT 5-Hydroxytryptamine Monoamine Neurotransmitter Pfizer ssri 5-HT Transporters

2 Citations for Sertraline hydrochloride

Citations are publications that use Tocris products. Selected citations for Sertraline hydrochloride include:

Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150

Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366 PMID: 25762681


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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Sertraline hydrochloride

Protocols

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