SDZ SER 082 fumarate

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Cat.No. 1255 - SDZ SER 082 fumarate | C15H20N2.C4H4O4 | CAS No. 1417343-80-6
Description: Selective 5-HT2B/2C antagonist
Chemical Name: (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine fumarate
Literature (3)

Biological Activity

Selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M. Wt 344.41
Formula C15H20N2.C4H4O4
Storage Store at RT
CAS Number 1417343-80-6
PubChem ID 45073480
Smiles C(\C=C\C(O[H])=O)(O[H])=O.[H][C@@]23[C@@](CCN(C3)C)([H])CN(CC4)C1=C4C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 344.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.52 mL 29.04 mL
5 mM 0.58 mL 2.9 mL 5.81 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References are publications that support the biological activity of the product.

Kalkman et al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201 PMID: 9570468

Mora et al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051 PMID: 9408213

Nozulak et al (1995) (+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity. J.Med.Chem. 38 28 PMID: 7837236

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