Discontinued ProductUnfortunately SD 169 (Cat. No. 2938) has been withdrawn from sale for commercial reasons.
Selective, orally active, ATP-competitive inhibitor of p38α MAPK (IC50 values are 3.2, 122 and > 50000 nM for p38α, p38β and p38γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 160.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.24 mL||31.22 mL||62.43 mL|
|5 mM||1.25 mL||6.24 mL||12.49 mL|
|10 mM||0.62 mL||3.12 mL||6.24 mL|
|50 mM||0.12 mL||0.62 mL||1.25 mL|
References are publications that support the products' biological activity.
Myers et al (2003) Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp.Neurol. 184 606 PMID: 14769353
Medicherla et al (2006) Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J.Pharmacol.Exp.Ther. 318 99 PMID: 16603672
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Keywords: SD 169, supplier, Selective, orally, active, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, p38, SD169, p38, p38, Tocris Bioscience
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Literature in this Area
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.