SD 169

Discontinued Product

Unfortunately SD 169 (Cat. No. 2938) has been withdrawn from sale for commercial reasons.
Cat.No. 2938 - SD 169 | C9H8N2O | CAS No. 1670-87-7
Description: Selective, orally active p38α inhibitor
Chemical Name: 1H-Indole-5-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38α MAPK (IC50 values are 3.2, 122 and > 50000 nM for p38α, p38β and p38γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

Technical Data

M. Wt 160.17
Formula C9H8N2O
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1670-87-7
Smiles NC(C1=CC=C(NC=C2)C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 160.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.24 mL 31.22 mL 62.43 mL
5 mM 1.25 mL 6.24 mL 12.49 mL
10 mM 0.62 mL 3.12 mL 6.24 mL
50 mM 0.12 mL 0.62 mL 1.25 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Myers et al (2003) Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp.Neurol. 184 606 PMID: 14769353

Medicherla et al (2006) Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J.Pharmacol.Exp.Ther. 318 99 PMID: 16603672

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Keywords: SD 169, supplier, Selective, orally, active, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, p38, SD169, p38, Tocris Bioscience

Citations for SD 169

Citations are publications that use Tocris products.

Currently there are no citations for SD 169.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
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Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SD 169

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

Protocols

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