SD 169

Discontinued Product

SD 169 (Cat. No. 2938) has been withdrawn from sale for commercial reasons.
Cat.No. 2938 - SD 169 | C9H8N2O | CAS No. 1670-87-7
Description: Selective, orally active p38α inhibitor
Chemical Name: 1H-Indole-5-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38α MAPK (IC50 values are 3.2, 122 and > 50000 nM for p38α, p38β and p38γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

Technical Data

M. Wt 160.17
Formula C9H8N2O
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1670-87-7
Smiles NC(C1=CC=C(NC=C2)C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Myers et al (2003) Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp.Neurol. 184 606 PMID: 14769353

Medicherla et al (2006) Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J.Pharmacol.Exp.Ther. 318 99 PMID: 16603672

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Citations for SD 169

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SD 169

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.