Potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.9 mL||19.51 mL||39.02 mL|
|5 mM||0.78 mL||3.9 mL||7.8 mL|
|10 mM||0.39 mL||1.95 mL||3.9 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97 PMID: 15100159
If you know of a relevant reference for SCS, please let us know.
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Keywords: Selective GABAA receptor antagonists beta1-subunit-selective Receptors GABAA Receptors
2 Citations for SCS
Citations are publications that use Tocris products. Selected citations for SCS include:
Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071 PMID: 22691495
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8 PMID: 25887256
Do you know of a great paper that uses SCS from Tocris? If so please let us know.
Literature in this Area
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.