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Cat.No. 2143 - SCS | C14H12N2O3 | CAS No. 3232-36-8
Description: Potent GABAA antagonist; β1-subunit selective
Chemical Name: Salicylidene salicylhydrazide
Citations (2)
Literature (7)

Biological Activity for SCS

SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.

Technical Data for SCS

M. Wt 256.26
Formula C14H12N2O3
Storage Store at RT
CAS Number 3232-36-8
PubChem ID 252156309
Smiles OC1=CC=CC=C1\C=N\NC(=O)C1=CC=CC=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SCS

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.81 50

Preparing Stock Solutions for SCS

The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.8 mL 39.02 mL 78.05 mL
2.5 mM 1.56 mL 7.8 mL 15.61 mL
5 mM 0.78 mL 3.9 mL 7.8 mL
25 mM 0.16 mL 0.78 mL 1.56 mL

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References for SCS

References are publications that support the biological activity of the product.

Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97 PMID: 15100159

If you know of a relevant reference for SCS, please let us know.

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Keywords: SCS, SCS supplier, Selective, GABAA, receptor, antagonists, beta1-subunit-selective, Receptors, 2143, Tocris Bioscience

2 Citations for SCS

Citations are publications that use Tocris products. Selected citations for SCS include:

Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8 PMID: 25887256

Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071 PMID: 22691495

Do you know of a great paper that uses SCS from Tocris? Please let us know.

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*Please note that Tocris will only send literature to established scientific business / institute addresses.

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