Potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.9 mL||19.51 mL||39.02 mL|
|5 mM||0.78 mL||3.9 mL||7.8 mL|
|10 mM||0.39 mL||1.95 mL||3.9 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References are publications that support the products' biological activity.
Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97 PMID: 15100159
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Keywords: SCS, supplier, Selective, GABAA, receptor, antagonists, beta1-subunit-selective, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
2 Citations for SCS
Citations are publications that use Tocris products. Selected citations for SCS include:
Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071 PMID: 22691495
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8 PMID: 25887256
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