SCS

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Cat.No. 2143 - SCS | C14H12N2O3 | CAS No. 3232-36-8
Description: Selective GABAA receptor antagonist; β1-subunit-selective
Chemical Name: Salicylidene salicylhydrazide
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.

Compound Libraries

SCS is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 256.26
Formula C14H12N2O3
Storage Store at RT
CAS Number 3232-36-8
PubChem ID 252156309
InChI Key OMCYEZUIYGPHDJ-OQLLNIDSSA-N
Smiles OC1=CC=CC=C1\C=N\NC(=O)C1=CC=CC=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.81 50

Preparing Stock Solutions

The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.9 mL 19.51 mL 39.02 mL
5 mM 0.78 mL 3.9 mL 7.8 mL
10 mM 0.39 mL 1.95 mL 3.9 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97 PMID: 15100159


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Keywords: Selective GABAA receptor antagonists beta1-subunit-selective Receptors GABAA Receptors

2 Citations for SCS

Citations are publications that use Tocris products. Selected citations for SCS include:

Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071 PMID: 22691495

Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8 PMID: 25887256


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Reviews

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Pathways for SCS

Protocols

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