SCH 50911

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Cat.No. 0984 - SCH 50911 | C8H15NO3 | CAS No. 733717-87-8
Description: Selective and competitive GABAB antagonist; orally bioavailable
Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity: ≥98%
Datasheet
Citations (10)
Reviews
Literature (6)

Biological Activity

A selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.

Licensing Information

Sold with the permission of Schering Plough Corporation

Technical Data

M. Wt 173.21
Formula C8H15NO3
Storage Desiccate at -20°C
Purity ≥98%
CAS Number 733717-87-8
PubChem ID 5311429
InChI Key SEYCKMQSPUVYEF-LURJTMIESA-N
Smiles [H][C@]1(CC(O)=O)CNC(C)(C)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.32 100
phosphate buffered saline 17.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.77 mL 28.87 mL 57.73 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
10 mM 0.58 mL 2.89 mL 5.77 mL
50 mM 0.12 mL 0.58 mL 1.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bolser et al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393 PMID: 7562513

Hosford et al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399 PMID: 7562514

Ong et al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35 PMID: 9865527

Blythin et al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 6 1529


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Keywords: SCH 50911, SCH 50911 supplier, Selective, competitive, orally, active, GABAB, antagonist, Receptors, SCH50911, 0984, Tocris Bioscience

10 Citations for SCH 50911

Citations are publications that use Tocris products. Selected citations for SCH 50911 include:

Jaiswal et al (2015) Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. J Psychopharmacol 9 127 PMID: 25914623

Ding et al (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. Br J Pharmacol 29 725 PMID: 25922425

Gryder et al (2005) Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. Toxins (Basel) 94 1728 PMID: 16045445

Margeta-Mitrovic et al (2001) Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Front Cell Neurosci 98 14643 PMID: 11724957


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