SCH 50911

Pricing Availability   Qty
Description: Selective and competitive GABAB antagonist; orally bioavailable
Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity: ≥98%
Citations (10)
Literature (6)

Biological Activity for SCH 50911

SCH 50911 is a selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.

Licensing Information

Sold with the permission of Schering Plough Corporation

Technical Data for SCH 50911

M. Wt 173.21
Formula C8H15NO3
Storage Desiccate at -20°C
Purity ≥98%
CAS Number 733717-87-8
PubChem ID 5311429
Smiles [H][C@]1(CC(O)=O)CNC(C)(C)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SCH 50911

Solvent Max Conc. mg/mL Max Conc. mM
water 17.32 100
phosphate buffered saline 17.32 100

Preparing Stock Solutions for SCH 50911

The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.77 mL 28.87 mL 57.73 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
10 mM 0.58 mL 2.89 mL 5.77 mL
50 mM 0.12 mL 0.58 mL 1.15 mL

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Product Datasheets for SCH 50911

Certificate of Analysis / Product Datasheet
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References for SCH 50911

References are publications that support the biological activity of the product.

Bolser et al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393 PMID: 7562513

Hosford et al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399 PMID: 7562514

Ong et al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35 PMID: 9865527

Blythin et al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 6 1529

If you know of a relevant reference for SCH 50911, please let us know.

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Keywords: SCH 50911, SCH 50911 supplier, Selective, competitive, orally, active, GABAB, antagonist, Receptors, SCH50911, 0984, Tocris Bioscience

10 Citations for SCH 50911

Citations are publications that use Tocris products. Selected citations for SCH 50911 include:

Kreye et al (2016) Human cerebrospinal fluid monoclonal N-MthD.-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain 139 2641 PMID: 27543972

Jaiswal et al (2015) Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. J Psychopharmacol 9 127 PMID: 25914623

Ding et al (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. Br J Pharmacol 29 725 PMID: 25922425

Gryder et al (2005) Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. Toxins (Basel) 94 1728 PMID: 16045445

Do you know of a great paper that uses SCH 50911 from Tocris? Please let us know.

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Literature in this Area

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