SCH 50911

Pricing Availability   Qty
Description: Selective and competitive GABAB antagonist; orally bioavailable
Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity: ≥98%
Citations (10)
Literature (2)

Biological Activity for SCH 50911

SCH 50911 is a selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.

Licensing Information

Sold with the permission of Schering Plough Corporation

Technical Data for SCH 50911

M. Wt 173.21
Formula C8H15NO3
Storage Desiccate at -20°C
Purity ≥98%
CAS Number 733717-87-8
PubChem ID 5311429
Smiles [H][C@]1(CC(O)=O)CNC(C)(C)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SCH 50911

Solvent Max Conc. mg/mL Max Conc. mM
water 17.32 100
phosphate buffered saline 17.32 100

Preparing Stock Solutions for SCH 50911

The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.77 mL 28.87 mL 57.73 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
10 mM 0.58 mL 2.89 mL 5.77 mL
50 mM 0.12 mL 0.58 mL 1.15 mL

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Product Datasheets for SCH 50911

Certificate of Analysis / Product Datasheet
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References for SCH 50911

References are publications that support the biological activity of the product.

Bolser et al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393 PMID: 7562513

Hosford et al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399 PMID: 7562514

Ong et al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35 PMID: 9865527

Blythin et al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 6 1529

If you know of a relevant reference for SCH 50911, please let us know.

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Keywords: SCH 50911, SCH 50911 supplier, Selective, competitive, orally, active, GABAB, antagonist, Receptors, SCH50911, 0984, Tocris Bioscience

10 Citations for SCH 50911

Citations are publications that use Tocris products. Selected citations for SCH 50911 include:

Kreye et al (2016) Human cerebrospinal fluid monoclonal N-MthD.-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain 139 2641 PMID: 27543972

Yu et al (2016) Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis 89 23 PMID: 26804027

Margeta-Mitrovic et al (2001) Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Front Cell Neurosci 98 14643 PMID: 11724957

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurochem 131 1050 PMID: 11082110

Do you know of a great paper that uses SCH 50911 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.