CGP 35348

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Cat.No. 1245 - CGP 35348 | C8H20NO4P | CAS No. 123690-79-9
Description: Brain penetrant, selective GABAB antagonist
Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Datasheet
Citations (7)
Literature

Biological Activity

Selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M. Wt 225.22
Formula C8H20NO4P
Storage Store at RT
CAS Number 123690-79-9
PubChem ID 107699
InChI Key QIIVUOWTHWIXFO-UHFFFAOYSA-N
Smiles NCCCP(C(OCC)OCC)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 225.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.2 mL 44.4 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hao et al (1994) Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 182 299 PMID: 7715832

Olpe et al (1990) CGP 35348: a centrally active blocker of GABAB receptors. Eur.J.Pharmacol. 187 27 PMID: 2176979

Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609 PMID: 10341258

Sutor and Luhmann (1998) Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 10 3417 PMID: 9824455


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Keywords: Brain penetrant selective GABAB antagonists Receptors CGP35348 GABAB Receptors

7 Citations for CGP 35348

Citations are publications that use Tocris products. Selected citations for CGP 35348 include:

Huang et al (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Br J Pharmacol 10 413 PMID: 25654758

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996

Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. Neuron 5 5732 PMID: 25501034

Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Cell Metab 78 807 PMID: 23764286

Gantz et al (2011) Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci 31 12629 PMID: 21880923

Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634 PMID: 17596413

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Nat Commun 131 1050 PMID: 11082110


Do you know of a great paper that uses CGP 35348 from Tocris? If so please let us know.

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