CGP 35348

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Cat.No. 1245 - CGP 35348 | C8H20NO4P | CAS No. 123690-79-9
Description: Selective GABAB antagonist; brain penetrant
Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Datasheet
Citations (11)
Reviews
Literature (6)

Biological Activity

Selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M. Wt 225.22
Formula C8H20NO4P
Storage Store at RT
CAS Number 123690-79-9
PubChem ID 107699
InChI Key QIIVUOWTHWIXFO-UHFFFAOYSA-N
Smiles NCCCP(C(OCC)OCC)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 225.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.2 mL 44.4 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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References

References are publications that support the biological activity of the product.

Hao et al (1994) Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 182 299 PMID: 7715832

Olpe et al (1990) CGP 35348: a centrally active blocker of GABAB receptors. Eur.J.Pharmacol. 187 27 PMID: 2176979

Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609 PMID: 10341258

Sutor and Luhmann (1998) Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 10 3417 PMID: 9824455


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Keywords: CGP 35348, CGP 35348 supplier, Brain, penetrant, selective, GABAB, antagonists, Receptors, CGP35348, 1245, Tocris Bioscience

11 Citations for CGP 35348

Citations are publications that use Tocris products. Selected citations for CGP 35348 include:

Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634 PMID: 17596413

Huang et al (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Br J Pharmacol 10 413 PMID: 25654758

Gaier et al (2010) Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci 30 13656 PMID: 20943906

Zhao et al (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience 6 138 PMID: 30240608


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