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Submit ReviewSCH 202676 hydrobromide
Description: Inhibitor of ligand binding to G-protein-coupled receptors
Chemical Name: N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Purity: ≥99% (HPLC)
Biological Activity
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).
Compound Libraries
SCH 202676 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 348.26 |
| Formula | C15H13N3S.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 265980-25-4 |
| PubChem ID | 9884675 |
| InChI Key | YJYGOWVFDGULLL-UHFFFAOYSA-N |
| Smiles | C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.71 | 25 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 348.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.49 mL | 57.43 mL | 114.86 mL |
| 1.25 mM | 2.3 mL | 11.49 mL | 22.97 mL |
| 2.5 mM | 1.15 mL | 5.74 mL | 11.49 mL |
| 12.5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Fawzi et al (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30 PMID: 11125021
Gao et al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 74 3173 PMID: 15081581
Lewandowicz et al (2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147 422 PMID: 16402041
If you know of a relevant reference for SCH 202676 hydrobromide, please let us know.
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Keywords: SCH 202676 hydrobromide, SCH 202676 hydrobromide supplier, inhibitors, inhibits, ligand, binding, G-protein-coupled, receptors, SCH202676, hydrobromide, Heterotrimeric, G-protein, GTPases, 1400, Tocris Bioscience
1 Citation for SCH 202676 hydrobromide
Citations are publications that use Tocris products. Selected citations for SCH 202676 hydrobromide include:
Müller et al (2018) Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation. Front Immunol 9 2520 PMID: 30450098
Do you know of a great paper that uses SCH 202676 hydrobromide from Tocris? Please let us know.
Reviews for SCH 202676 hydrobromide
Average Rating: 4 (Based on 1 Review.)
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Effective but not very stable.
By
Anonymous on 10/25/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hepatocyte
Used as GPCR inhibitor for Glucagon treatment in mouse primary hepatocytes. As shown in the picture, from left to right, 1st sample is untreated, 2nd sample was treated with Glucagon, 3rd sample was pre-treated with this chemical plus glucagon, seems pretty effective for inhibiting glucagon stimulated p-CREB activation. however this chemical is not very stable, seems to loose effectiveness after short storage. Overall is happy with this product.
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