Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSCH 202676 hydrobromide
Description: Inhibitor of ligand binding to G-protein-coupled receptors
Chemical Name: N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Purity: ≥99% (HPLC)
Biological Activity
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).
Compound Libraries
SCH 202676 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 348.26 |
| Formula | C15H13N3S.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 265980-25-4 |
| PubChem ID | 9884675 |
| InChI Key | YJYGOWVFDGULLL-UHFFFAOYSA-N |
| Smiles | C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.71 | 25 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 348.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.49 mL | 57.43 mL | 114.86 mL |
| 1.25 mM | 2.3 mL | 11.49 mL | 22.97 mL |
| 2.5 mM | 1.15 mL | 5.74 mL | 11.49 mL |
| 12.5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Fawzi et al (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30 PMID: 11125021
Gao et al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 74 3173 PMID: 15081581
Lewandowicz et al (2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147 422 PMID: 16402041
If you know of a relevant reference for SCH 202676 hydrobromide, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SCH 202676 hydrobromide, SCH 202676 hydrobromide supplier, inhibitors, inhibits, ligand, binding, G-protein-coupled, receptors, SCH202676, hydrobromide, Heterotrimeric, G-protein, GTPases, 1400, Tocris Bioscience
1 Citation for SCH 202676 hydrobromide
Citations are publications that use Tocris products. Selected citations for SCH 202676 hydrobromide include:
Müller et al (2018) Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation. Front Immunol 9 2520 PMID: 30450098
Do you know of a great paper that uses SCH 202676 hydrobromide from Tocris? Please let us know.
Reviews for SCH 202676 hydrobromide
Average Rating: 4 (Based on 1 Review.)
Have you used SCH 202676 hydrobromide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Effective but not very stable.
By
Anonymous on 10/25/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hepatocyte
Used as GPCR inhibitor for Glucagon treatment in mouse primary hepatocytes. As shown in the picture, from left to right, 1st sample is untreated, 2nd sample was treated with Glucagon, 3rd sample was pre-treated with this chemical plus glucagon, seems pretty effective for inhibiting glucagon stimulated p-CREB activation. however this chemical is not very stable, seems to loose effectiveness after short storage. Overall is happy with this product.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pain Research Product GuideUpdated
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling