SCH 202676 hydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 1400 - SCH 202676 hydrobromide | C15H13N3S.HBr | CAS No. 265980-25-4
Description: Inhibitor of ligand binding to G-protein-coupled receptors
Chemical Name: N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).

Compound Libraries

SCH 202676 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 348.26
Formula C15H13N3S.HBr
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 265980-25-4
PubChem ID 9884675
InChI Key YJYGOWVFDGULLL-UHFFFAOYSA-N
Smiles C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.71 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 348.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.36 mL 28.71 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fawzi et al (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30 PMID: 11125021

Gao et al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 74 3173 PMID: 15081581

Lewandowicz et al (2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147 422 PMID: 16402041


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Keywords: SCH 202676 hydrobromide, supplier, inhibitors, inhibits, ligand, binding, G-protein-coupled, receptors, SCH202676, hydrobromide, G, Protein, (Heterotrimeric), G, Protein, (Heterotrimeric), Tocris Bioscience

Citations for SCH 202676 hydrobromide

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