Pricing Availability   Qty
Cat.No. 7232 - SBP1-FITCSBP1-FITC | FITC-PEG4-Ile-Glu-Glu-Gln-Ala-Lys-Thr-Phe-Leu-Asp-Lys-Phe-Asn-His-Glu-Ala-Glu-Asp-Leu-Phe-Tyr-Gln-Ser-NH2
Description: Fluorescent ACE2-derived peptide; binds receptor binding domain of SARS-CoV-2 spike protein
Purity: ≥95% (HPLC)

Biological Activity

Fluorescently labelled peptide derived from human ACE2 (SBP1, Cat. No. 7233). Composed of SBP1 conjugated to FITC (Fluorescein-5-isothiocyanate; Cat. No. 5440). SBP1 binds receptor binding domain (RBD) of insect-derived SARS-CoV-2 spike protein (KD = 1.3 μM for N-terminal biotinylated, insect-derived spike protein RBD; see Zhang et al preprint publication).

Please note - unpublished, in-house data suggests SBP1 has approximately 75-fold lower affinity for insect-derived SARS-CoV-2 RBD than reported by Zhang et al.

Technical Data

M. Wt 3438.68
Formula C159H217N33O51S

(Modifications: Ile-1 = FITC-PEG4-Ile, Ser-23 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC(CCOCCOCCOCCOCCNC(NC(C=C6C(O)=O)=CC=C6C(C7=CC=C(O)C=C7O8)=C(C=C9)C8=CC9=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 0.1M PBS (pH 7.4)


References are publications that support the biological activity of the product.

Zhang et al (2020) The first-in-class peptide binder to the SARS-CoV-2 spike protein. BioRxiv - Paper not yet peer reviewed.

If you know of a relevant reference for SBP1-FITC, please let us know.

Keywords: SBP1-FITC SBP1-FITC, SBP1-FITC SBP1-FITC supplier, spike, binding, protein, SARS-CoV-2, receptor, domain, RBD, COVID-19, severe, acute, respiratory, syndrome, ACE2, peptide, fluorescently-labeled, flluorescence, Enzyme, Probes, and, Substrates, 7232, Tocris Bioscience

Citations for SBP1-FITC

Citations are publications that use Tocris products.

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