Discontinued Product

SBP1 (Cat. No. 7233) has been withdrawn from sale for commercial reasons.
Description: ACE2 derived peptide; binds SARS-CoV-2 spike protein receptor binding domain
Purity: ≥95% (HPLC)

Biological Activity for SBP1

SBP1 is a human ACE2 receptor-derived 23-amino acid peptide. Binds receptor binding domain (RBD) of insect-derived SARS-CoV-2 spike protein (KD = 1.3 μM for N-terminal biotinylated, insect-derived spike protein RBD; see Zhang et al preprint publication).

Please note - unpublished, in-house data suggests approximately 75-fold lower affinity for insect-derived SARS-CoV-2 RBD than reported by Zhang et al.

Technical Data for SBP1

M. Wt 2802.05
Formula C127H185N31O41

(Modifications: Ser-23 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SBP1

Certificate of Analysis / Product Datasheet
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References for SBP1

References are publications that support the biological activity of the product.

Zhang et al (2020) Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD. BioRxiv - Paper not yet peer reviewed

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Keywords: SBP1, SBP1 supplier, spike, binding, protein, SARS-CoV-2, receptor, domain, RBD, COVID-19, severe, acute, respiratory, syndrome, ACE2, peptide, fluorescent, FITC, 7233, Tocris Bioscience

Citations for SBP1

Citations are publications that use Tocris products.

Currently there are no citations for SBP1.

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