SBHA

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Cat.No. 3810 - SBHA | C8H16N2O4 | CAS No. 38937-66-5
Description: HDAC1/3 inhibitor
Chemical Name: N,N'-Dihydroxyoctanediamide
Datasheet
Citations
Reviews
Literature

Biological Activity

Histone deacetylase (HDAC) inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (Cat. No. 3257) in colorectal cancer cells.

Compound Libraries

SBHA is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 204.22
Formula C8H16N2O4
Storage Store at +4°C
CAS Number 38937-66-5
PubChem ID 5173
InChI Key IDQPVOFTURLJPT-UHFFFAOYSA-N
Smiles O=C(CCCCCCC(NO)=O)NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.42 100
DMSO 20.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 204.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.48 mL 48.97 mL
5 mM 0.98 mL 4.9 mL 9.79 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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References

References are publications that support the biological activity of the product.

Zhang et al (2004) The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol.Cancer.Ther. 3 425 PMID: 15078986

Brinkmann et al (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J.Biol.Chem. 276 22491 PMID: 11304533

Richon et al (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc.Natl.Acad.Sci.U.S.A 95 3003 PMID: 9501205


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Citations for SBHA

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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