SB 258719 hydrochloride

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Cat.No. 2726 - SB 258719 hydrochloride | C18H30N2O2S.HCl | CAS No. 1217674-10-6
Description: Selective 5-HT7 antagonist
Chemical Name: 3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity

Selective 5-HT7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 374.97
Formula C18H30N2O2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1217674-10-6
PubChem ID 56972181
Smiles O=S(C1=CC(C)=CC=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.5 100
ethanol 37.5 100
water 37.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 374.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.33 mL 26.67 mL
5 mM 0.53 mL 2.67 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Forbes et al (1998) (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist. J.Med.Chem. 41 655 PMID: 9513592

Thomas et al (1998) Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br.J.Pharmacol. 124 1300 PMID: 9720804

Guscott et al (2003) The hypothermic effect of 5-CT in mice is mediated through the 5-HT7receptor. Neuropharmacology 44 1031 PMID: 12763096

If you know of a relevant reference for SB 258719 hydrochloride, please let us know.

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3 Citations for SB 258719 hydrochloride

Citations are publications that use Tocris products. Selected citations for SB 258719 hydrochloride include:

Domínguez-Soto (2017) Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis. Sci Rep 7 14761 PMID: 29116249

Zhao et al (2015) Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system. Front Synaptic Neurosci 5 9043 PMID: 25761874

Johnson et al (2011) Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience 192 372 PMID: 21749913

Do you know of a great paper that uses SB 258719 hydrochloride from Tocris? If so please let us know.

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