SB 215505

Discontinued Product

SB 215505 (Cat. No. 1374) has been withdrawn from sale for commercial reasons.
Cat.No. 1374 - SB 215505 | C19H16ClN3O | CAS No. 162100-15-4
Description: 5-HT2B/2C antagonist
Chemical Name: 6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). Increases wakefulness and motor activity in rats. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 337.81
Formula C19H16ClN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 162100-15-4
PubChem ID 10449757
InChI Key HOVMHIRTZYQSKM-UHFFFAOYSA-N
Smiles O=C(NC3=CC=CC4=C3C=CC=N4)N(CC2)C1=C2C=C(C)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID: 9886683

Reavill et al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572 PMID: 10188965

Kantor et al (2004) Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. Br.J.Pharmacol. 142 1332 PMID: 15265808

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Citations for SB 215505

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Currently there are no citations for SB 215505.

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