Sakura 6

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Description: Promoter of SERT and nNOS interaction
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for Sakura 6

Sakura 6 is a synthetic serotonin transporter (SERT)-binding peptide. Promotes interaction of SERT and neuronal nitric oxide synthase, reducing SERT activity and cell surface SERT, increases auto-inhibition, reduces synaptic 5-HT release and reduces firing in the dorsal raphe nucleus. Induces an acute depressive phenotype in a mouse model of depression.

Technical Data for Sakura 6

M. Wt 599.73
Formula C31H45N5O7
Sequence ADWV

(Modifications: Ala-1= N-Cyclohexylethyl-Ala)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2490708-79-5
Smiles O=C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C(C)C)C(O)=O)=O)=O)[C@H](C)NCCC3CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sakura 6

Solubility Soluble to 1 mg/ml in 0.01M PBS (pH 7.4)

References for Sakura 6

References are publications that support the biological activity of the product.

Sun et al (2022) Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science 378 390 PMID: 36302033

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Keywords: Sakura 6, Sakura 6 supplier, sakura6, sert, serotonin, transporter, nNOS, neuronal, nitric, oxide, synthase, peptide, 5HT, autoinhibition, depressant, DRN, dorsal, raphe, nucleus, 5-HT, Transporters, 7897, Tocris Bioscience

Citations for Sakura 6

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.