(S)-SNAP 5114

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Cat.No. 1561 - (S)-SNAP 5114 | C30H35NO6 | CAS No. 157604-55-2
Description: GABA uptake inhibitor
Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.

Technical Data

M. Wt 505.61
Formula C30H35NO6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 157604-55-2
PubChem ID 10458835
InChI Key VDLDUZLDZBVOAS-QFIPXVFZSA-N
Smiles O=[C@]([C@@H]1CN(CCOC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C2=CC=C(OC)C=C2)CCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 25.28 50
DMSO 50.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 505.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207 PMID: 7874447

Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335 PMID: 8939442

Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399 PMID: 10974324


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Keywords: (S)-SNAP 5114, (S)-SNAP 5114 supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-2, GAT-3, Transporters, Monoamine, Neurotransmitter, (S)-SNAP5114, 1561, Tocris Bioscience

5 Citations for (S)-SNAP 5114

Citations are publications that use Tocris products. Selected citations for (S)-SNAP 5114 include:

Kersanté et al (2013) A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Neurophysiol 591 2429 PMID: 23381899

Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Physiol 36 607 PMID: 26758848

Kékesi et al (2015) Recurrent seizure-like events are associated with coupled astroglial synchronization. J Neurosci 9 215 PMID: 26150770

Kinney (2005) GAT-3 transporters regulate inhibition in the neocortex. Mol Pain 94 4533 PMID: 16135550

Herd et al (2013) Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. J Neurosci 33 14850 PMID: 24027285


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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