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Discontinued Product(S)-HexylHIBO (Cat. No. 1750) has been withdrawn from sale for commercial reasons.
Biological Activity for (S)-HexylHIBO
Group I mGlu receptor antagonist (Kb values are 30 and 61 μM at mGlu1a and mGlu5a receptors respectively).
Racemate also available.
Technical Data for (S)-HexylHIBO
|Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for (S)-HexylHIBO
References are publications that support the biological activity of the product.
Madsen et al (2001) Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors J.Med.Chem. 44 1051 PMID: 11297452
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Keywords: (S)-HexylHIBO, (S)-HexylHIBO supplier, Group, I, mGlur, antagonists, Receptors, mGlu1, mGluR1, mGlu5, mGluR5, Glutamate, Metabotropic, (S)-Hexylhomoibotenic, acid, (Metabotropic), 1750, Tocris Bioscience
Citations for (S)-HexylHIBO
Citations are publications that use Tocris products.
Currently there are no citations for (S)-HexylHIBO.
Reviews for (S)-HexylHIBO
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.