S 38093

Discontinued Product

6778 has been discontinued.

View all Histamine H<sub>3</sub> Receptors products.
Description: Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive
Chemical Name: rel-4-[3-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for S 38093

S 38093 is a H3 antagonist and inverse agonist (Ki values are 8.8, 1.2 and 1.44 μM, at rat, human and mouse, respectively). Exhibits no activity at other histaminergic receptors. Antagonizes agonist action at mouse H3 receptors (KB = 0.65 μM). Displays inverse agonist action in cells expressing a high H3 receptor density, (EC50 values are 9 and 1.7 μM, at human and rat H3 receptors, respectively). Exhibits antihyperalgesic effect in a mouse diabetic neuropathy model in vivo. Promotes hippocampal neurogenesis in a mouse Alzheimer's disease model. Antinociceptive and procognitive. Also σ1 receptor antagonist. Exhibits ~30-fold selecitivity for σ1 over H3 and occupies σ1 but not H3 receptors at procognitive does in mice.

Technical Data for S 38093

M. Wt 288.39
Formula C17H24N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1403835-45-9
PubChem ID 70941112
InChI Key MRNMYWNBLVJWKG-GASCZTMLSA-N
Smiles [H][C@@]12CCC[C@@]1(CN(C2)CCCOC3=CC=C(C(N)=O)C=C3)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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View all Histamine H3 Receptor Antagonists

Keywords: S 38093, S 38093 supplier, S38093, H3, agonists, Receptors, Histamine, histaminergic, selective, antagonists, antagonism, inverse, agonism, antinociceptive, σ1, sigma1, procognitive, Sigma1, 6778, Tocris Bioscience

Citations for S 38093

Citations are publications that use Tocris products.

Currently there are no citations for S 38093.

Reviews for S 38093

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.