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Submit ReviewS 38093
Discontinued Product
6778 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive
Chemical Name: rel-4-[3-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy]benzamide
Purity: ≥98% (HPLC)
Biological Activity for S 38093
S 38093 is a H3 antagonist and inverse agonist (Ki values are 8.8, 1.2 and 1.44 μM, at rat, human and mouse, respectively). Exhibits no activity at other histaminergic receptors. Antagonizes agonist action at mouse H3 receptors (KB = 0.65 μM). Displays inverse agonist action in cells expressing a high H3 receptor density, (EC50 values are 9 and 1.7 μM, at human and rat H3 receptors, respectively). Exhibits antihyperalgesic effect in a mouse diabetic neuropathy model in vivo. Promotes hippocampal neurogenesis in a mouse Alzheimer's disease model. Antinociceptive and procognitive. Also σ1 receptor antagonist. Exhibits ~30-fold selecitivity for σ1 over H3 and occupies σ1 but not H3 receptors at procognitive does in mice.
Technical Data for S 38093
| M. Wt | 288.39 |
| Formula | C17H24N2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1403835-45-9 |
| PubChem ID | 70941112 |
| InChI Key | MRNMYWNBLVJWKG-GASCZTMLSA-N |
| Smiles | [H][C@@]12CCC[C@@]1(CN(C2)CCCOC3=CC=C(C(N)=O)C=C3)[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for S 38093
References for S 38093
References are publications that support the biological activity of the product.
Guilloux et al (2017) S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci.Rep. 7 42946 PMID: 28218311
Chaumette et al (2018) Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. Eur.J.Pain. 22 127 PMID: 28877402
Guilloux et al (2017) S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci.Rep. 7 42946 PMID: 28218311
Riddy et al (2019) Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists. Neuropharmacology 144 244 PMID: 30359639
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Keywords: S 38093, S 38093 supplier, S38093, H3, agonists, Receptors, Histamine, histaminergic, selective, antagonists, antagonism, inverse, agonism, antinociceptive, σ1, sigma1, procognitive, Sigma1, 6778, Tocris Bioscience
Citations for S 38093
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Currently there are no citations for S 38093.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.