S 32212 hydrochloride

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Description: 5-HT2C inverse agonist; α2-adrenoceptor antagonist
Chemical Name: 1,2-Dihydro-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3H-benz[e]indole-3-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity for S 32212 hydrochloride

S 32212 hydrochloride is an inverse agonist of 5-HT2C receptors (pKi = 8.18 at human 5-HT2C INI receptors). Also an antagonist of human α2-adrenoceptors. Displays negligible affinity for α1A-adrenoceptors, histamine H1 receptors and muscarinic M1 receptors.

Technical Data for S 32212 hydrochloride

M. Wt 452.98
Formula C25H28N4O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 847871-78-7
PubChem ID 11487816
Smiles CN(CC2)CCN2C1=C(OC)C=CC(NC(N3C(C=CC5=C4C=CC=C5)=C4CC3)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for S 32212 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 11.32 25
DMSO 11.32 25

Preparing Stock Solutions for S 32212 hydrochloride

The following data is based on the product molecular weight 452.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.83 mL 44.15 mL 88.3 mL
1.25 mM 1.77 mL 8.83 mL 17.66 mL
2.5 mM 0.88 mL 4.42 mL 8.83 mL
12.5 mM 0.18 mL 0.88 mL 1.77 mL

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Product Datasheets for S 32212 hydrochloride

References for S 32212 hydrochloride

References are publications that support the biological activity of the product.

Millan et al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization. J.Pharmacol.Exp.Ther. 340 750 PMID: 22178752

Dekeyne et al (2012) S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization. J.Pharmacol.Exp.Ther. 340 765 PMID: 22178753

If you know of a relevant reference for S 32212 hydrochloride, please let us know.

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Citations for S 32212 hydrochloride

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