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Cat.No. 2609 - Ryuvidine | C15H12N2O2S | CAS No. 265312-55-8
Description: SETD8 inhibitor; also CDK4 inhibitor
Chemical Name: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

Compound Libraries

Ryuvidine is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 284.33
Formula C15H12N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 265312-55-8
PubChem ID 481747
Smiles CC1=NC2=C(S1)C(=O)C=C(NC1=CC=C(C)C=C1)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.69 20
ethanol 1.42 5

Preparing Stock Solutions

The following data is based on the product molecular weight 284.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Ryu et al (2000) 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg.Med.Chem.Lett. 10 461 PMID: 10743948

Blum et al (2014) Small-molecule inhibitors of SETD8 with cellular activity. ASC.Chem.Biol. [Epub ahead of print] 9 2471 PMID: 25137013

If you know of a relevant reference for Ryuvidine, please let us know.

View Related Products by Product Action

View all Other Lysine Methyltransferase Inhibitors

Keywords: Ryuvidine, supplier, Cyclin-dependent, protein, kinase, 4, cdk4, inhibitors, SETD8, protein, lysine, methyltransferases, inhibits, SPS8I2, Cyclin-dependent, Kinase, Lysine, Methyltransferases, Other, Lysine, Methyltransferases, Other, Lysine, Methyltransferases, Tocris Bioscience

1 Citation for Ryuvidine

Citations are publications that use Tocris products. Selected citations for Ryuvidine include:

FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048

Do you know of a great paper that uses Ryuvidine from Tocris? If so please let us know.

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