Discontinued Product

RVD-Hpα (Cat. No. 3744) has been withdrawn from sale for commercial reasons.
Cat.No. 3744 - RVD-Hpalpha | Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His | CAS No. 1193362-76-3
Description: Selective CB1 agonist; also CB2 PAM
Alternative Names: Pepcan-12
Literature (6)

Biological Activity for RVD-Hpα

RVD-Hpα is a N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. Also high affinity CB2 positive allosteric modulator (Ki = 50 nM).

Technical Data for RVD-Hpα

M. Wt 1424.66
Formula C65H105N19O17
Storage Store at -20°C
CAS Number 1193362-76-3
PubChem ID 90488874
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RVD-Hpα

Certificate of Analysis / Product Datasheet
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References for RVD-Hpα

References are publications that support the biological activity of the product.

Gomes et al (2009) Novel endogenous peptide agonists of cannabinoid receptors. FASEB J. 23 3020 PMID: 19380512

Khurana et al (2017) Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities. Neuropharmacology 124 3 PMID: 28527758

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Keywords: RVD-Hpalpha, RVD-Hpalpha supplier, selective, CB1, receptors, agonists, cannabinoids, RVD-Hpalpha, RVD-Hpα, cb1r, high, affinity, CB2, positive, allosteric, modulator, PAM, endocannabinoids, Pepcan-12, Receptors, 3744, Tocris Bioscience

Citations for RVD-Hpα

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Currently there are no citations for RVD-Hpα.

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