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Description: Caged nicotine; rapidly excitable by visible light
Chemical Name: Bis(2,2'-bipyridine-N,N')bis(S-nicotine-N1) ruthenium(2+) dichloride
Citations (1)

Biological Activity for RuBi-Nicotine

RuBi-Nicotine is a ruthenium-bisbipyridine-caged nicotine, excitable by irradiation with visible light. Undergoes rapid photolysis to release nicotine (< 20 ns); exhibits a high quantum yield. Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1 mM.

Licensing Information

Sold under licence from Columbia University

Technical Data for RuBi-Nicotine

M. Wt 808.81
Formula C40H44Cl2N8Ru
Storage Store at -20°C
CAS Number 1256362-30-7
PubChem ID 90488888
Smiles [Cl-].[Cl-].[Ru++].C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.[H][C@]1(CCCN1C)C1=CC=CN=C1.[H][C@]1(CCCN1C)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RuBi-Nicotine

Solvent Max Conc. mg/mL Max Conc. mM
water 40.44 50

Preparing Stock Solutions for RuBi-Nicotine

The following data is based on the product molecular weight 808.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.47 mL 12.36 mL 24.73 mL
2.5 mM 0.49 mL 2.47 mL 4.95 mL
5 mM 0.25 mL 1.24 mL 2.47 mL
25 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for RuBi-Nicotine

Certificate of Analysis / Product Datasheet
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References for RuBi-Nicotine

References are publications that support the biological activity of the product.

Filevich et al (2010) A caged nicotine with nanosecond range kinetics and visible light sensitivity. J.Inorg.Biochem. 104 1248 PMID: 20825994

If you know of a relevant reference for RuBi-Nicotine, please let us know.

Keywords: RuBi-Nicotine, RuBi-Nicotine supplier, RuBiNicotine, caged, compounds, nicotinics, cholinergics, acetylcholine, receptors, nAChRs, agonist, excitatory, Nicotinic, Receptors, (Non-selective), Caged, Compounds, 3855, Tocris Bioscience

1 Citation for RuBi-Nicotine

Citations are publications that use Tocris products. Selected citations for RuBi-Nicotine include:

Lorna W et al (2022) Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections. Front Neural Circuits 16 978837 PMID: 36213206

Do you know of a great paper that uses RuBi-Nicotine from Tocris? Please let us know.

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