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Cat.No. 3855 - RuBi-Nicotine | C40H44Cl2N8Ru | CAS No. 1256362-30-7
Description: Caged nicotine; rapidly excitable by visible light
Chemical Name: Bis(2,2'-bipyridine-N,N')bis(S-nicotine-N1) ruthenium(2+) dichloride

Biological Activity

Ruthenium-bisbipyridine-caged nicotine, excitable by irradiation with visible light. Undergoes rapid photolysis to release nicotine (< 20 ns); exhibits a high quantum yield. Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1 mM.

Licensing Information

Sold under licence from Columbia University

Technical Data

M. Wt 808.81
Formula C40H44Cl2N8Ru
Storage Store at -20°C
CAS Number 1256362-30-7
PubChem ID 90488888
Smiles [Cl-].[Cl-].[Ru++].C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.[H][C@]1(CCCN1C)C1=CC=CN=C1.[H][C@]1(CCCN1C)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 40.44 50

Preparing Stock Solutions

The following data is based on the product molecular weight 808.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.18 mL 12.36 mL
5 mM 0.25 mL 1.24 mL 2.47 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Filevich et al (2010) A caged nicotine with nanosecond range kinetics and visible light sensitivity. J.Inorg.Biochem. 104 1248 PMID: 20825994

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Keywords: RuBiNicotine caged compounds nicotinics cholinergics acetylcholine receptors nAChRs agonist excitatory Nicotinic Receptors (Non-selective)

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