(-)-Nicotine ditartrate

Pricing Availability Delivery Time Qty
Cat.No. 3546 - (-)-Nicotine ditartrate | C10H14N2.2C4H6O6 | CAS No. 65-31-6
Description: Prototypical nAChR agonist
Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

Technical Data

M. Wt 462.41
Formula C10H14N2.2C4H6O6
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 65-31-6
PubChem ID 11957628
InChI Key RFEJUZJILGIRHQ-OMDKHLBYSA-N
Smiles CN(CCC2)[C@@H]2[C@]1=CC=CN=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.68 75
water 46.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 462.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.81 mL 21.63 mL
5 mM 0.43 mL 2.16 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 285 777 PMID: 9580626

Xiao et al (1998) Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 54 322 PMID: 9687574

Mayhan (1999) Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 133 48 PMID: 10385481


If you know of a relevant reference for (-)-Nicotine ditartrate, please let us know.

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Keywords: (-)-Nicotine ditartrate, supplier, α4β2, agonists, a4b2, alpha4beta2, Nicotinic, Receptors, Acetylcholine, nAChR, Nicotinic, (a4b2), Receptors, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience

5 Citations for (-)-Nicotine ditartrate

Citations are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600

Tang et al (2015) Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Iran Biomed J 36 800 PMID: 25948478

Chalabi-Yani et al (2015) Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats. Elife 19 214 PMID: 26210948

Leão et al (2012) OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci 15 1524 PMID: 23042082

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698


Do you know of a great paper that uses (-)-Nicotine ditartrate from Tocris? If so please let us know.

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for (-)-Nicotine ditartrate

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