(-)-Nicotine ditartrate

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Cat.No. 3546 - (-)-Nicotine ditartrate | C10H14N2.2C4H6O6 | CAS No. 65-31-6
Description: Prototypical nAChR agonist
Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Purity: ≥99% (HPLC)
Citations (7)
Literature (3)

Biological Activity for (-)-Nicotine ditartrate

(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

Technical Data for (-)-Nicotine ditartrate

M. Wt 462.41
Formula C10H14N2.2C4H6O6
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 65-31-6
PubChem ID 11957628
Smiles CN(CCC2)[C@@H]2[C@]1=CC=CN=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (-)-Nicotine ditartrate

Solvent Max Conc. mg/mL Max Conc. mM
water 46.24 100
DMSO 34.68 75

Preparing Stock Solutions for (-)-Nicotine ditartrate

The following data is based on the product molecular weight 462.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.81 mL 21.63 mL
5 mM 0.43 mL 2.16 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for (-)-Nicotine ditartrate

Certificate of Analysis / Product Datasheet
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References for (-)-Nicotine ditartrate

References are publications that support the biological activity of the product.

Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 285 777 PMID: 9580626

Xiao et al (1998) Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 54 322 PMID: 9687574

Mayhan (1999) Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 133 48 PMID: 10385481

If you know of a relevant reference for (-)-Nicotine ditartrate, please let us know.

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Keywords: (-)-Nicotine ditartrate, (-)-Nicotine ditartrate supplier, α4β2, agonists, a4b2, alpha4beta2, Nicotinic, Receptors, Acetylcholine, nAChR, (a4b2), (Non-selective), 3546, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Nicotine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

7 Citations for (-)-Nicotine ditartrate

Citations are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:

Dorst et al (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun 11 5113 PMID: 33037215

Gu et al (2019) α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep 26 866 PMID: 30673609

Leão et al (2012) OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci 15 1524 PMID: 23042082

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698

Do you know of a great paper that uses (-)-Nicotine ditartrate from Tocris? Please let us know.

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Literature in this Area

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