RuBi-5-HT

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Cat.No. 3856 - RuBi-5-HT | C33H37F12N6OP3Ru
Description: RuBi-caged serotonin
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-5-hydroxytryptamine ruthenium(2+) dihexafluorophosphate complex
Datasheet
Citations (1)
Literature

Biological Activity

RuBi-caged version of serotonin (Cat. No. 3547). Excited by visible wavelengths (450 nm). Has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907 (Cat. No. 4173).

Licensing Information

Sold under licence from Columbia University

Technical Data

M. Wt 955.66
Formula C33H37F12N6OP3Ru
Storage Store at -20°C
PubChem ID 91826073
InChI Key CNCGWUINLFSMHP-UHFFFAOYSA-N
Smiles [Ru++].CP(C)C.F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.NCCC1=CNC2=C1C=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.56 10

Preparing Stock Solutions

The following data is based on the product molecular weight 955.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.23 mL 10.46 mL
5 mM 0.21 mL 1.05 mL 2.09 mL
10 mM 0.1 mL 0.52 mL 1.05 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zayat et al (2006) Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines. Inorg. Chem. 45 1728 PMID: 16471986

Cabrera et al (2017) A visible-light-sensitive caged serotonin. ACS Chem.Neurosci. 8 1036 PMID: 28460173


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Keywords: caged serotonin compounds neurotransmitters 5-HT receptors serotonergic Non-selective 5-HT

1 Citation for RuBi-5-HT

Citations are publications that use Tocris products. Selected citations for RuBi-5-HT include:

Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600 PMID: 22318196


Do you know of a great paper that uses RuBi-5-HT from Tocris? If so please let us know.

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for RuBi-5-HT

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