RuBi-caged version of serotonin (Cat. No. 3547). Excited by visible wavelengths (450 nm). Has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907 (Cat. No. 4173).
Sold under licence from Columbia University
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 955.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.05 mL||5.23 mL||10.46 mL|
|5 mM||0.21 mL||1.05 mL||2.09 mL|
|10 mM||0.1 mL||0.52 mL||1.05 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Zayat et al (2006) Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines. Inorg. Chem. 45 1728 PMID: 16471986
Cabrera et al (2017) A visible-light-sensitive caged serotonin. ACS Chem.Neurosci. 8 1036 PMID: 28460173
If you know of a relevant reference for RuBi-5-HT, please let us know.
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Keywords: caged serotonin compounds neurotransmitters 5-HT receptors serotonergic Non-selective 5-HT
1 Citation for RuBi-5-HT
Citations are publications that use Tocris products. Selected citations for RuBi-5-HT include:
Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600 PMID: 22318196
Do you know of a great paper that uses RuBi-5-HT from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.