Serotonin hydrochloride

Pricing Availability   Qty
Description: Endogenous 5-HT receptor agonist
Alternative Names: 5-Hydroxytryptamine, 5-HT
Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Purity: ≥99% (HPLC)
Citations (12)
Reviews (1)
Literature (3)

Biological Activity for Serotonin hydrochloride

Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).

Technical Data for Serotonin hydrochloride

M. Wt 212.68
Formula C10H12N2O.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 153-98-0
PubChem ID 160436
Smiles NCCC2=CNC1=CC=C(O)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Serotonin hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 21.27 100
DMSO 21.27 100

Preparing Stock Solutions for Serotonin hydrochloride

The following data is based on the product molecular weight 212.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.7 mL 23.51 mL 47.02 mL
5 mM 0.94 mL 4.7 mL 9.4 mL
10 mM 0.47 mL 2.35 mL 4.7 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets for Serotonin hydrochloride

Certificate of Analysis / Product Datasheet
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References for Serotonin hydrochloride

References are publications that support the biological activity of the product.

Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083 PMID: 10462127

If you know of a relevant reference for Serotonin hydrochloride, please let us know.

View Related Products by Product Action

View all Non-selective 5-HT Agonists

Keywords: Serotonin hydrochloride, Serotonin hydrochloride supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, 5-Hydroxytryptamine, 5-HT3, Receptors, Transporters, 3547, Tocris Bioscience

12 Citations for Serotonin hydrochloride

Citations are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:

Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077

Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144

Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224

Do you know of a great paper that uses Serotonin hydrochloride from Tocris? Please let us know.

Reviews for Serotonin hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Works well and affordable.
By Anonymous on 05/23/2019
Assay Type: Ex Vivo
Species: Mouse

Excellent product and affordable. Worked quite effectively for our ephys work, robustly hyperpolarizing neurons in control condition as expected.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
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  • GPCR Signaling
5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.