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Submit ReviewSerotonin hydrochloride
Description: Endogenous 5-HT receptor agonist
Alternative Names: 5-Hydroxytryptamine, 5-HT
Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Serotonin hydrochloride
Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).
Technical Data for Serotonin hydrochloride
| M. Wt | 212.68 |
| Formula | C10H12N2O.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 153-98-0 |
| PubChem ID | 160436 |
| InChI Key | MDIGAZPGKJFIAH-UHFFFAOYSA-N |
| Smiles | NCCC2=CNC1=CC=C(O)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Serotonin hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.27 | 100 | |
| DMSO | 21.27 | 100 |
Preparing Stock Solutions for Serotonin hydrochloride
The following data is based on the product molecular weight 212.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.7 mL | 23.51 mL | 47.02 mL |
| 5 mM | 0.94 mL | 4.7 mL | 9.4 mL |
| 10 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
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Product Datasheets for Serotonin hydrochloride
References for Serotonin hydrochloride
References are publications that support the biological activity of the product.
Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083 PMID: 10462127
If you know of a relevant reference for Serotonin hydrochloride, please let us know.
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Keywords: Serotonin hydrochloride, Serotonin hydrochloride supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, 5-Hydroxytryptamine, 5-HT3, Receptors, Transporters, 3547, Tocris Bioscience
27 Citations for Serotonin hydrochloride
Citations are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Am J Physiol Regul Integr Comp Physiol 9 251 PMID: 24330646
Bryan L et al (2022) Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors. Cell Rep 40 111211 PMID: 35977511
Hongyan et al (2022) Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord. Curr Biol 32 1038-1048.e2 PMID: 35104440
Bernardo L et al (2022) Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system. Neuron 110 1371-1384.e7 PMID: 35120627
T et al (2015) Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice. Acta Physiol (Oxf) 215 133-43 PMID: 26052659
Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID: 21931717
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039
Chang et al (2019) A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila. Curr Biol 29 3635-3646.e5 PMID: 31668619
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
Bart C et al (2019) Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology 44 1742-1751 PMID: 30959513
Hao et al (2019) A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron 102 745-761.e8 PMID: 30922875
Sean P et al (2018) Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell 34 659-673.e6 PMID: 30270124
Heath D et al (2021) Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology 187 108477 PMID: 33581143
Lin et al (2021) Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Rep 37 109997 PMID: 34788630
Wieland B et al (2020) Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex. Neuron 108 1113-1129.e6 PMID: 33080227
David S et al (2020) NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Cell Rep 32 108025 PMID: 32783947
Sanjeev et al (2020) The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens. Cell Host Microbe 28 41-53.e8 PMID: 32521224
Haynes et al (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. BMC Vet Res 4 PMID: 25564731
Gene J et al (2019) Differential serotonin transporter (5-HTT) and 5-HT2 receptor density in limbic and neocortical areas of adults and children with autism spectrum disorders: implications for selective serotonin reuptake inhibitor efficacy. J Neurochem 151 642-655 PMID: 31325179
Yin et al (2017) Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex 27 509 PMID: 26494800
Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125 PMID: 22917617
Gerhold et al (2015) Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude. J Neurosci 35 9580 PMID: 26134641
Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144
Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224
Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Do you know of a great paper that uses Serotonin hydrochloride from Tocris? Please let us know.
Reviews for Serotonin hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Works well and affordable.
By
Anonymous on 05/23/2019
Assay Type: Ex Vivo
Species: Mouse
Excellent product and affordable. Worked quite effectively for our ephys work, robustly hyperpolarizing neurons in control condition as expected.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.