Endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 212.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.7 mL||23.51 mL||47.02 mL|
|5 mM||0.94 mL||4.7 mL||9.4 mL|
|10 mM||0.47 mL||2.35 mL||4.7 mL|
|50 mM||0.09 mL||0.47 mL||0.94 mL|
References are publications that support the products' biological activity.
Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083 PMID: 10462127
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Keywords: Serotonin hydrochloride, supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, 5-Hydroxytryptamine, 5-HT, Non-selective, 5-HT, 5-HT3, Receptors, 5-HT, Transporters, Non-selective, 5-HT, Tocris Bioscience
7 Citations for Serotonin hydrochloride
Citations are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Am J Physiol Regul Integr Comp Physiol 9 251 PMID: 24330646
Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125 PMID: 22917617
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID: 21931717
Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144
Gerhold et al (2015) Pronociceptive and antinociceptive effects of buprenorphine in the spinal cord dorsal horn cover a dose range of four orders of magnitude. J Neurosci 35 9580 PMID: 26134641
Haynes et al (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. BMC Vet Res 4 PMID: 25564731
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039
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Serotonin hydrochloride Reviews
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Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.