Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSerotonin hydrochloride
Description: Endogenous 5-HT receptor agonist
Alternative Names: 5-Hydroxytryptamine, 5-HT
Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Serotonin hydrochloride
Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).
Technical Data for Serotonin hydrochloride
| M. Wt | 212.68 |
| Formula | C10H12N2O.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 153-98-0 |
| PubChem ID | 160436 |
| InChI Key | MDIGAZPGKJFIAH-UHFFFAOYSA-N |
| Smiles | NCCC2=CNC1=CC=C(O)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Serotonin hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.27 | 100 | |
| DMSO | 21.27 | 100 |
Preparing Stock Solutions for Serotonin hydrochloride
The following data is based on the product molecular weight 212.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.7 mL | 23.51 mL | 47.02 mL |
| 5 mM | 0.94 mL | 4.7 mL | 9.4 mL |
| 10 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Serotonin hydrochloride
References for Serotonin hydrochloride
References are publications that support the biological activity of the product.
Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083 PMID: 10462127
If you know of a relevant reference for Serotonin hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Serotonin hydrochloride, Serotonin hydrochloride supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, 5-Hydroxytryptamine, 5-HT3, Receptors, Transporters, 3547, Tocris Bioscience
12 Citations for Serotonin hydrochloride
Citations are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077
Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144
Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039
Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125 PMID: 22917617
Yin et al (2017) Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex 27 509 PMID: 26494800
Gerhold et al (2015) Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude. J Neurosci 35 9580 PMID: 26134641
Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Am J Physiol Regul Integr Comp Physiol 9 251 PMID: 24330646
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID: 21931717
Haynes et al (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. BMC Vet Res 4 PMID: 25564731
Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685
Do you know of a great paper that uses Serotonin hydrochloride from Tocris? Please let us know.
Reviews for Serotonin hydrochloride
Average Rating: 5 (Based on 1 Review.)
Have you used Serotonin hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Works well and affordable.
By
Anonymous on 05/23/2019
Assay Type: Ex Vivo
Species: Mouse
Excellent product and affordable. Worked quite effectively for our ephys work, robustly hyperpolarizing neurons in control condition as expected.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.