Water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP (Cat. No. 0940), a voltage-dependent K+ channel blocker.
Sold under licence from Columbia University
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 672.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.49 mL||7.43 mL||14.87 mL|
|5 mM||0.3 mL||1.49 mL||2.97 mL|
|10 mM||0.15 mL||0.74 mL||1.49 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482
If you know of a relevant reference for RuBi-4AP, please let us know.
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Keywords: RuBi-4AP, supplier, voltage-dependent, gated, K+, potassium, channel, blockers, caged, 4-aminopyridine, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, Rubi-4-aminopyridine, Voltage-Gated, Potassium, Channels, Tocris Bioscience
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.