RuBi-4AP

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Cat.No. 3557 - RuBi-4AP | C30H28Cl2N8Ru | CAS No. 851956-02-0
Description: Caged 4-aminopyridine; a non-selective KV channel blocker
Alternative Names: Rubi-4-aminopyridine
Chemical Name: bis(2,2'-Bipyridine-N,N')bis(4-aminopyridine-N1) ruthenium(2+) dichloride complex
Datasheet
Citations
Reviews
Literature

Biological Activity

Water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP (Cat. No. 0940), a voltage-dependent K+ channel blocker.

Licensing Information

Sold under licence from Columbia University

Technical Data

M. Wt 672.58
Formula C30H28Cl2N8Ru
Storage Store at -20°C
CAS Number 851956-02-0
PubChem ID 11422486
InChI Key MVEGPXUCOGNVKR-UHFFFAOYSA-L
Smiles [Cl-].[Cl-].[Ru++].NC1=CC=NC=C1.NC1=CC=NC=C1.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.18 30

Preparing Stock Solutions

The following data is based on the product molecular weight 672.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 4.96 mL 24.78 mL 49.56 mL
1.5 mM 0.99 mL 4.96 mL 9.91 mL
3 mM 0.5 mL 2.48 mL 4.96 mL
15 mM 0.1 mL 0.5 mL 0.99 mL

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References

References are publications that support the biological activity of the product.

Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482

Nikolenko et al (2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem.Commun. 13 1752


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View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Blockers

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Citations for RuBi-4AP

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