RuBi-4AP
Biological Activity
Water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP (Cat. No. 0940), a voltage-dependent K+ channel blocker.
Licensing Information
Sold under licence from Columbia University
Technical Data
| M. Wt | 672.58 |
| Formula | C30H28Cl2N8Ru |
| Storage | Store at -20°C |
| CAS Number | 851956-02-0 |
| PubChem ID | 11422486 |
| InChI Key | MVEGPXUCOGNVKR-UHFFFAOYSA-L |
| Smiles | [Cl-].[Cl-].[Ru++].NC1=CC=NC=C1.NC1=CC=NC=C1.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.18 | 30 |
Preparing Stock Solutions
The following data is based on the product molecular weight 672.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.49 mL | 7.43 mL | 14.87 mL |
| 5 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 10 mM | 0.15 mL | 0.74 mL | 1.49 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482
Nikolenko et al (2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem.Commun. 13 1752 PMID:
If you know of a relevant reference for RuBi-4AP, please let us know.
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Keywords: voltage-dependent gated K+ potassium channel blockers caged 4-aminopyridine hERG Human Ether-A-Go-Go Gene KCNQ Rubi-4-aminopyridine Voltage-Gated Potassium Channels
Citations for RuBi-4AP
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