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Submit ReviewWater soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP (Cat. No. 0940), a voltage-dependent K+ channel blocker.
Sold under licence from Columbia University
M. Wt | 672.58 |
Formula | C30H28Cl2N8Ru |
Storage | Store at -20°C |
CAS Number | 851956-02-0 |
PubChem ID | 11422486 |
InChI Key | MVEGPXUCOGNVKR-UHFFFAOYSA-L |
Smiles | [Cl-].[Cl-].[Ru++].NC1=CC=NC=C1.NC1=CC=NC=C1.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482
Nikolenko et al (2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem.Commun. 13 1752
Keywords: RuBi-4AP, RuBi-4AP supplier, voltage-dependent, gated, K+, potassium, channel, blockers, caged, 4-aminopyridine, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, Rubi-4-aminopyridine, Voltage-Gated, Potassium, Channels, Other, Caged, Compounds, 3557, Tocris Bioscience
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
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