RSVA 405

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Cat.No. 5138 - RSVA 405 | C17H20N4O2 | CAS No. 140405-36-3
Description: AMPK activator; also STAT3 inhibitor
Chemical Name: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.

Technical Data

M. Wt 312.37
Formula C17H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 140405-36-3
PubChem ID 9613337
InChI Key GWQPCBPAOAFXSJ-XDHOZWIPSA-N
Smiles O=C(N/N=C/C2=C(O)C=C(N(CC)CC)C=C2)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.62 50
ethanol 1.56 5

Preparing Stock Solutions

The following data is based on the product molecular weight 312.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Vingtdeux et al (2011) Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J. 25 219 PMID: 20852062

Vingtdeux et al (2011) Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis. Mol Med 17 1022 PMID: 21647536

Capiralla et al (2012) Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FASEB J. 279 3791 PMID: 22909341


If you know of a relevant reference for RSVA 405, please let us know.

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View all AMPK Activators

Keywords: RSVA 405, supplier, RSVA405, AMP-activated, protein, kinases, activators, inhibitors, STAT3, indirect, Ab, Abeta, Aβ, amyloid, metabolism, nf-kb, nf-κb, cytokines, inhibits, AMPK, STAT, AMPK, Tocris Bioscience

1 Citation for RSVA 405

Citations are publications that use Tocris products. Selected citations for RSVA 405 include:

Dai et al (2017) Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy 13 1435 PMID: 28613987


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Reviews for RSVA 405

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for RSVA 405

AMPK

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.