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Description: Standard selective D2-like antagonist
Chemical Name: (RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
Purity: ≥98% (HPLC)
Citations (7)
Reviews (2)
Literature (2)

Biological Activity for (RS)-(±)-Sulpiride

(RS)-(±)-Sulpiride is a standard D2-like dopamine receptor antagonist.

S-enantiomer also available.

Compound Libraries for (RS)-(±)-Sulpiride

(RS)-(±)-Sulpiride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (RS)-(±)-Sulpiride

M. Wt 341.42
Formula C15H23N3O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 15676-16-1
PubChem ID 5355
Smiles CCN1CCCC1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (RS)-(±)-Sulpiride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.14 100

Preparing Stock Solutions for (RS)-(±)-Sulpiride

The following data is based on the product molecular weight 341.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.64 mL 29.29 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for (RS)-(±)-Sulpiride

Certificate of Analysis / Product Datasheet
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References for (RS)-(±)-Sulpiride

References are publications that support the biological activity of the product.

Seeman and Van Tol (1993) DA D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur.J.Pharmacol. 233 173 PMID: 8097160

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 9163

If you know of a relevant reference for (RS)-(±)-Sulpiride, please let us know.

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Keywords: (RS)-(±)-Sulpiride, (RS)-(±)-Sulpiride supplier, selective, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 0894, Tocris Bioscience

7 Citations for (RS)-(±)-Sulpiride

Citations are publications that use Tocris products. Selected citations for (RS)-(±)-Sulpiride include:

Zhang et al (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661

Leyrer-Jackson (2017) Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex. Physiol Rep 5 e13499 PMID: 29150590

Holroyd et al (2015) Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. Brain 40 1495 PMID: 25547712

Huang (2018) DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci 59 2623 PMID: 29847669

Do you know of a great paper that uses (RS)-(±)-Sulpiride from Tocris? Please let us know.

Reviews for (RS)-(±)-Sulpiride

Average Rating: 4 (Based on 2 Reviews.)

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Inhibition of Synaptic Transmission in the VP.
By Anonymous on 02/02/2020
Assay Type: In Vivo
Species: Mouse

sulpiride (1 μM)

PMID: 29949769
review image

Sulpiride reverses quinpirole effects on dopamine release.
By Anonymous on 03/28/2018
Assay Type: Ex Vivo
Species: Mouse

In voltammetry experiments measuring evoked dopamine release, quinpirole was used to activate D2 receptors to inhibit dopamine release. Sulpiride (600 nM) was applied afterward to reverse quinpirole effects.

We mix sulpiride at 2mM in ethanol. It goes into solution well.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.