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Biological Activity for (RS)-(±)-Sulpiride
(RS)-(±)-Sulpiride is a standard D2-like dopamine receptor antagonist.
S-enantiomer also available.
Compound Libraries for (RS)-(±)-Sulpiride
Technical Data for (RS)-(±)-Sulpiride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (RS)-(±)-Sulpiride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. HCl||17.07||50 with gentle warming|
Preparing Stock Solutions for (RS)-(±)-Sulpiride
The following data is based on the product molecular weight 341.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.93 mL||14.64 mL||29.29 mL|
|5 mM||0.59 mL||2.93 mL||5.86 mL|
|10 mM||0.29 mL||1.46 mL||2.93 mL|
|50 mM||0.06 mL||0.29 mL||0.59 mL|
Product Datasheets for (RS)-(±)-Sulpiride
References for (RS)-(±)-Sulpiride
References are publications that support the biological activity of the product.
Seeman and Van Tol (1993) DA D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur.J.Pharmacol. 233 173 PMID: 8097160
Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
Merck Index 12 9163
If you know of a relevant reference for (RS)-(±)-Sulpiride, please let us know.
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Keywords: (RS)-(±)-Sulpiride, (RS)-(±)-Sulpiride supplier, selective, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 0894, Tocris Bioscience
7 Citations for (RS)-(±)-Sulpiride
Citations are publications that use Tocris products. Selected citations for (RS)-(±)-Sulpiride include:
Holroyd et al (2015) Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. Brain 40 1495 PMID: 25547712
Huang (2018) DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci 59 2623 PMID: 29847669
Leyrer-Jackson (2017) Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex. Physiol Rep 5 e13499 PMID: 29150590
Zhang et al (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661
Shin et al (2011) Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor. Neuropsychopharmacology 20 130 PMID: 22110371
Zhang et al (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci 59 4441 PMID: 30193315
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Do you know of a great paper that uses (RS)-(±)-Sulpiride from Tocris? Please let us know.
Reviews for (RS)-(±)-Sulpiride
Average Rating: 4 (Based on 2 Reviews.)
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sulpiride (1 μM)
In voltammetry experiments measuring evoked dopamine release, quinpirole was used to activate D2 receptors to inhibit dopamine release. Sulpiride (600 nM) was applied afterward to reverse quinpirole effects.
We mix sulpiride at 2mM in ethanol. It goes into solution well.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.