(RS)-Baclofen

Pricing Availability Delivery Time Qty
Cat.No. 0417 - (RS)-Baclofen | C10H12ClNO2 | CAS No. 1134-47-0
Description: Selective GABAB agonist
Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (14)
Literature

Biological Activity

Selective GABAB receptor agonist. Skeletal muscle relaxant. (R)-Baclofen (Cat. No. 0796) also available.

Technical Data

M. Wt 213.66
Formula C10H12ClNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1134-47-0
PubChem ID 2284
InChI Key KPYSYYIEGFHWSV-UHFFFAOYSA-N
Smiles OC(CC(CN)C1=CC=C(Cl)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 213.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.68 mL 23.4 mL 46.8 mL
5 mM 0.94 mL 4.68 mL 9.36 mL
10 mM 0.47 mL 2.34 mL 4.68 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Berthelot et al (1991) 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies. J.Med.Chem. 34 2557 PMID: 1652022

Bowery et al (1993) GABAB receptor pharmacology. Annu.Rev.Pharmacol.Toxicol. 33 109 PMID: 8388192

Hill et al (1981) 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290 149 PMID: 6259535


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Keywords: (RS)-Baclofen, supplier, Selective, GABAB, agonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience

14 Citations for (RS)-Baclofen

Citations are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

Wojnicki et al (2013) Baclofen-induced reductions in optional food intake depend upon food composition. Appetite 64 62 PMID: 23321345

Zemoura et al (2013) Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem 288 34897 PMID: 24114844

Baloucoune et al (2012) GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS One 7 e39698 PMID: 22761875

Takesian et al (2010) Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci 30 2716 PMID: 20164356

Tu et al (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30 749 PMID: 20071540

Olmos-Serrano et al (2010) Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. Neuropharmacology 30 9929 PMID: 20660275

Bray and Mynlieff (2009) Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus. Dev Neurobiol 69 885 PMID: 19777558

Petzold et al (2008) Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. J Neurosci 58 897 PMID: 18579080

Maher and Westbrook (2008) Co-transmission of dopamine and GABA in periglomerular cells. J Neurosci 99 1559 PMID: 18216231

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047 PMID: 17178407

Rubio et al (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci 35 5625 PMID: 25855177

Terunuma et al (2015) Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Front Cell Neurosci 88 74 PMID: 25261019

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. J Neurophysiol 9 115 PMID: 25918499

Baquero et al (2015) Developmental changes in synaptic distribution in arcuate nucleus neurons. Neuropsychopharmacology 35 8558 PMID: 26041922


Do you know of a great paper that uses (RS)-Baclofen from Tocris? If so please let us know.

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