Pricing Availability Delivery Time Qty
Cat.No. 0417 - (RS)-Baclofen | C10H12ClNO2 | CAS No. 1134-47-0
Description: Selective GABAB agonist
Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity: ≥99% (HPLC)
Citations (14)

Biological Activity

Selective GABAB receptor agonist. Skeletal muscle relaxant.

R-enantiomer also available.

Technical Data

M. Wt 213.66
Formula C10H12ClNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1134-47-0
PubChem ID 2284
Smiles OC(CC(CN)C1=CC=C(Cl)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 213.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.68 mL 23.4 mL 46.8 mL
5 mM 0.94 mL 4.68 mL 9.36 mL
10 mM 0.47 mL 2.34 mL 4.68 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Berthelot et al (1991) 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies. J.Med.Chem. 34 2557 PMID: 1652022

Bowery et al (1993) GABAB receptor pharmacology. Annu.Rev.Pharmacol.Toxicol. 33 109 PMID: 8388192

Hill et al (1981) 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290 149 PMID: 6259535

If you know of a relevant reference for (RS)-Baclofen, please let us know.

View Related Products by Target

View Related Products by Product Action

View all GABAB Receptor Agonists

Keywords: (RS)-Baclofen, supplier, Selective, GABAB, agonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience

14 Citations for (RS)-Baclofen

Citations are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

Takesian et al (2010) Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci 30 2716 PMID: 20164356

Tu et al (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30 749 PMID: 20071540

Terunuma et al (2015) Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Front Cell Neurosci 88 74 PMID: 25261019

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. J Neurophysiol 9 115 PMID: 25918499

Baquero et al (2015) Developmental changes in synaptic distribution in arcuate nucleus neurons. Neuropsychopharmacology 35 8558 PMID: 26041922

Wojnicki et al (2013) Baclofen-induced reductions in optional food intake depend upon food composition. Appetite 64 62 PMID: 23321345

Zemoura et al (2013) Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem 288 34897 PMID: 24114844

Rubio et al (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci 35 5625 PMID: 25855177

Baloucoune et al (2012) GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS One 7 e39698 PMID: 22761875

Olmos-Serrano et al (2010) Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. Neuropharmacology 30 9929 PMID: 20660275

Bray and Mynlieff (2009) Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus. Dev Neurobiol 69 885 PMID: 19777558

Petzold et al (2008) Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. J Neurosci 58 897 PMID: 18579080

Maher and Westbrook (2008) Co-transmission of dopamine and GABA in periglomerular cells. J Neurosci 99 1559 PMID: 18216231

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047 PMID: 17178407

Do you know of a great paper that uses (RS)-Baclofen from Tocris? If so please let us know.

Reviews for (RS)-Baclofen

There are currently no reviews for this product. Be the first to review (RS)-Baclofen and earn rewards!

Have you used (RS)-Baclofen?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.