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Description: Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
Alternative Names: STX 209
Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity: ≥99% (HPLC)
Citations (14)
Reviews (1)
Literature (2)

Biological Activity for (R)-Baclofen

More active enantiomer of (RS)-Baclofen, a selective GABAB agonist.

Racemate also available.

Technical Data for (R)-Baclofen

M. Wt 213.66
Formula C10H12ClNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 69308-37-8
PubChem ID 44602
Smiles NC[C@@](CC(O)=O)([H])C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-Baclofen

Solvent Max Conc. mg/mL Max Conc. mM
water 4.27 20 with gentle warming

Preparing Stock Solutions for (R)-Baclofen

The following data is based on the product molecular weight 213.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 23.4 mL 117.01 mL 234.02 mL
1 mM 4.68 mL 23.4 mL 46.8 mL
2 mM 2.34 mL 11.7 mL 23.4 mL
10 mM 0.47 mL 2.34 mL 4.68 mL

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Product Datasheets for (R)-Baclofen

Certificate of Analysis / Product Datasheet
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References for (R)-Baclofen

References are publications that support the biological activity of the product.

Falch et al (1986) Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J.Neurochem. 47 898 PMID: 3016189

Hong et al (1991) Effects of phaclofen and the enantiomers of bac. on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur.J.Pharmacol. 196 267 PMID: 1654254

If you know of a relevant reference for (R)-Baclofen, please let us know.

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Keywords: (R)-Baclofen, (R)-Baclofen supplier, Selective, GABAB, agonists, Receptors, STX209, STX, 209, 0796, Tocris Bioscience

14 Citations for (R)-Baclofen

Citations are publications that use Tocris products. Selected citations for (R)-Baclofen include:

Hensler et al (2012) GABAB receptor-positive modulators: brain region-dependent effects. J Pharmacol Exp Ther 340 19 PMID: 21954301

Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

Bragina et al (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9 345 PMID: 26388733

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585

Klug et al (2012) Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One 7 e45323 PMID: 23028932

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Front Cell Neurosci 5 10468 PMID: 26020477

Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Mol Cell Neurosci 9 188 PMID: 26041994

Kirwan et al (2015) Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro. J Pharmacol Exp Ther 142 3178 PMID: 26395144

Messer and Levine (2012) Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neurosci Res 90 1454 PMID: 22388975

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996

Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons. J Neurophysiol 104 403 PMID: 20445035

Bartoi et al (2010) GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. J Biol Chem 285 20625 PMID: 20406808

Pacey et al (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Sci Rep 338 897 PMID: 21636656

Do you know of a great paper that uses (R)-Baclofen from Tocris? Please let us know.

Reviews for (R)-Baclofen

Average Rating: 4 (Based on 1 Review.)

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GABAb specific agonist.
By Anonymous on 10/22/2018
Assay Type: Ex Vivo
Species: Mouse

Used to activate GABAb, direct application. Although it did not trigger any response, neither did GABA and this was expected, used it to confirm GABAb is not involved in our assay.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.