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Cat.No. 1394 - (RS)-3,4-DCPG | C10H9NO6 | CAS No. 176796-64-8
Description: Potent systemically active anticonvulsant. Racemate of (R)-3,4,-DCPG (Cat. No. 1395)
Chemical Name: (RS)-3,4-Dicarboxyphenylglycine
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Systemically active anticonvulsant that is 30-100-fold more potent in vivo than the separate enantiomers (S)-3,4-DCPG or (R)-3,4,-DCPG.

S-enantiomer and R-enantiomer also available.

Technical Data

M. Wt 239.18
Formula C10H9NO6
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 176796-64-8
PubChem ID 3313698
Smiles NC(C(O)=O)C1=CC=C(C(O)=O)C(=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 50 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902

Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991

Thomas et al (1998) Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots. Neuropharmacology 37 1223 PMID: 9849660

If you know of a relevant reference for (RS)-3,4-DCPG, please let us know.

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Keywords: (RS)-3,4-DCPG, (RS)-3,4-DCPG supplier, Potent, systemically, active, anticonvulsant, Racemate, Glutamate, Ionotropic, Non-Selective, iGlur, Receptors, Group, III, mGluR8, mGlu8, Metabotropic, antagonists, Non-selective, (Metabotropic), 1394, Tocris Bioscience

1 Citation for (RS)-3,4-DCPG

Citations are publications that use Tocris products. Selected citations for (RS)-3,4-DCPG include:

Gosnell et al (2011) mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology 36 1599 PMID: 21451497

Do you know of a great paper that uses (RS)-3,4-DCPG from Tocris? Please let us know.

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