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Description: AMPA antagonist/weak NMDA antagonist
Chemical Name: (R)-3,4-Dicarboxyphenylglycine
Purity: ≥96% (HPLC)
Biological Activity
AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors.
Racemate and S-enantiomer also available.
Technical Data
| M. Wt | 239.18 |
| Formula | C10H9NO6 |
| Storage | Desiccate at RT |
| Purity | ≥96% (HPLC) |
| CAS Number | 201730-10-1 |
| PubChem ID | 6604849 |
| InChI Key | IJVMOGKBEVRBPP-SSDOTTSWSA-N |
| Smiles | N[C@@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902
Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991
If you know of a relevant reference for (R)-3,4-DCPG, please let us know.
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Keywords: (R)-3,4-DCPG, (R)-3,4-DCPG supplier, AMPA, antagonists, weak, NMDA, Glutamate, Ionotropic, Non-Selective, iGlur, Receptors, Non-selective, 1395, Tocris Bioscience
1 Citation for (R)-3,4-DCPG
Citations are publications that use Tocris products. Selected citations for (R)-3,4-DCPG include:
Sun et al (2012) Structure based model for the prediction of phospholipidosis induction potential of small molecules. J Chem Inf Model 52 1798 PMID: 22725677
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