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Cat.No. 1395 - (R)-3,4-DCPG | C10H9NO6 | CAS No. 201730-10-1
Description: AMPA antagonist/weak NMDA antagonist
Chemical Name: (R)-3,4-Dicarboxyphenylglycine
Purity: ≥96% (HPLC)
Citations (1)

Biological Activity

AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors.

Racemate and S-enantiomer also available.

Technical Data

M. Wt 239.18
Formula C10H9NO6
Storage Desiccate at RT
Purity ≥96% (HPLC)
CAS Number 201730-10-1
PubChem ID 6604849
Smiles N[C@@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 239.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.9 mL 41.81 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902

Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991

If you know of a relevant reference for (R)-3,4-DCPG, please let us know.

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Keywords: (R)-3,4-DCPG, supplier, AMPA, antagonists, weak, NMDA, Glutamate, Ionotropic, Non-Selective, iGlur, Receptors, Non-selective, Ionotropic, Glutamate, Non-selective, Ionotropic, Glutamate, Tocris Bioscience

1 Citation for (R)-3,4-DCPG

Citations are publications that use Tocris products. Selected citations for (R)-3,4-DCPG include:

Sun et al (2012) Structure based model for the prediction of phospholipidosis induction potential of small molecules. J Chem Inf Model 52 1798 PMID: 22725677

Do you know of a great paper that uses (R)-3,4-DCPG from Tocris? If so please let us know.

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