Pricing Availability   Qty
Cat.No. 1395 - (R)-3,4-DCPG | C10H9NO6 | CAS No. 201730-10-1
Description: AMPA antagonist/weak NMDA antagonist
Chemical Name: (R)-3,4-Dicarboxyphenylglycine
Purity: ≥96% (HPLC)
Citations (1)
Literature (5)

Biological Activity for (R)-3,4-DCPG

(R)-3,4-DCPG is a AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors.

Racemate and S-enantiomer also available.

Technical Data for (R)-3,4-DCPG

M. Wt 239.18
Formula C10H9NO6
Storage Desiccate at RT
Purity ≥96% (HPLC)
CAS Number 201730-10-1
PubChem ID 6604849
Smiles N[C@@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-3,4-DCPG

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for (R)-3,4-DCPG

The following data is based on the product molecular weight 239.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.9 mL 41.81 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for (R)-3,4-DCPG

Certificate of Analysis / Product Datasheet
Select another batch:

References for (R)-3,4-DCPG

References are publications that support the biological activity of the product.

Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902

Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991

If you know of a relevant reference for (R)-3,4-DCPG, please let us know.

View Related Products by Product Action

View all Non-selective Ionotropic Glutamate Antagonists

Keywords: (R)-3,4-DCPG, (R)-3,4-DCPG supplier, AMPA, antagonists, weak, NMDA, Glutamate, Ionotropic, Non-Selective, iGlur, Receptors, Non-selective, 1395, Tocris Bioscience

1 Citation for (R)-3,4-DCPG

Citations are publications that use Tocris products. Selected citations for (R)-3,4-DCPG include:

Sun et al (2012) Structure based model for the prediction of phospholipidosis induction potential of small molecules. J Chem Inf Model 52 1798 PMID: 22725677

Do you know of a great paper that uses (R)-3,4-DCPG from Tocris? Please let us know.

Reviews for (R)-3,4-DCPG

There are currently no reviews for this product. Be the first to review (R)-3,4-DCPG and earn rewards!

Have you used (R)-3,4-DCPG?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Parkinson's Poster

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.