RS 1

Discontinued Product

RS 1 (Cat. No. 5810) has been withdrawn from sale for commercial reasons.
Cat.No. 5810 - RS 1 | C20H16Br2N2O3S | CAS No. 312756-74-4
Description: High affinity RAD51 activator; also CRISPR enhancer
Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

Technical Data

M. Wt 524.23
Formula C20H16Br2N2O3S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 312756-74-4
PubChem ID 1039737
InChI Key SWKAVEUTKGKHSR-UHFFFAOYSA-N
Smiles BrC1=CC=C(C=C1)NC(C2=CC=C(C(S(=O)(NCC3=CC=CC=C3)=O)=C2)Br)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548 PMID: 26817820

Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848 PMID: 18840682

Keywords: RS 1, RS 1 supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, DNA,, RNA, and, Protein, Synthesis, Reagents, 5810, Tocris Bioscience

Citations for RS 1

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Currently there are no citations for RS 1.

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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