RS 1
Biological Activity
High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.
Technical Data
| M. Wt | 524.23 |
| Formula | C20H16Br2N2O3S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 312756-74-4 |
| PubChem ID | 1039737 |
| InChI Key | SWKAVEUTKGKHSR-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C=C1)NC(C2=CC=C(C(S(=O)(NCC3=CC=CC=C3)=O)=C2)Br)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 524.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.54 mL | 19.08 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548 PMID: 26817820
Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848 PMID: 18840682
If you know of a relevant reference for RS 1, please let us know.
View Related Products by Target
Keywords: RS 1, RS 1 supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, DNA,, RNA, and, Protein, Synthesis, Reagents, 5810, Tocris Bioscience
Citations for RS 1
Citations are publications that use Tocris products.
Currently there are no citations for RS 1. Do you know of a great paper that uses RS 1 from Tocris? Please let us know.
Reviews for RS 1
There are currently no reviews for this product. Be the first to review RS 1 and earn rewards!
Have you used RS 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
