Home / Cell Biology / Cell Metabolism / DNA, RNA and Protein Synthesis / RS 1

RS 1

Cat. No. 5810 Submit a Review Datasheet / COA / SDS

Discontinued Product

RS 1 (Cat. No. 5810) has been withdrawn from sale for commercial reasons.
Cat.No. 5810 - RS 1 | C20H16Br2N2O3S | CAS No. 312756-74-4
Description: High affinity RAD51 activator; also CRISPR enhancer
Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for RS 1

RS 1 is a high affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

Technical Data for RS 1

M. Wt 524.23
Formula C20H16Br2N2O3S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 312756-74-4
PubChem ID 1039737
InChI Key SWKAVEUTKGKHSR-UHFFFAOYSA-N
Smiles BrC1=CC=C(C=C1)NC(C2=CC=C(C(S(=O)(NCC3=CC=CC=C3)=O)=C2)Br)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RS 1

References are publications that support the biological activity of the product.

Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548 PMID: 26817820

Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848 PMID: 18840682

View Related Products by Target

Keywords: RS 1, RS 1 supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, DNA,, RNA, and, Protein, Synthesis, Reagents, 5810, Tocris Bioscience

Citations for RS 1

Citations are publications that use Tocris products.

Currently there are no citations for RS 1.

Reviews for RS 1

There are currently no reviews for this product. Be the first to review RS 1 and earn rewards!

Have you used RS 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis