RS 1

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Cat.No. 5810 - RS 1 | C20H16Br2N2O3S | CAS No. 312756-74-4
Description: High affinity RAD51 activator; also CRISPR enhancer
Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

Technical Data

M. Wt 524.23
Formula C20H16Br2N2O3S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 312756-74-4
PubChem ID 1039737
InChI Key SWKAVEUTKGKHSR-UHFFFAOYSA-N
Smiles BrC1=CC=C(C=C1)NC(C2=CC=C(C(S(=O)(NCC3=CC=CC=C3)=O)=C2)Br)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 524.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.54 mL 19.08 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548 PMID: 26817820

Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848 PMID: 18840682


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Citations for RS 1

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for RS 1

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