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Description: High affinity RAD51 activator; also CRISPR enhancer
Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Biological Activity
High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.
Technical Data
| M. Wt | 524.23 |
| Formula | C20H16Br2N2O3S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 312756-74-4 |
| PubChem ID | 1039737 |
| InChI Key | SWKAVEUTKGKHSR-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C=C1)NC(C2=CC=C(C(S(=O)(NCC3=CC=CC=C3)=O)=C2)Br)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 524.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.54 mL | 19.08 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548 PMID: 26817820
Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848 PMID: 18840682
If you know of a relevant reference for RS 1, please let us know.
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Citations for RS 1
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