Ro 3306

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Cat.No. 4181 - Ro 3306 | C18H13N3OS2 | CAS No. 872573-93-8
Description: Cdk1 inhibitor
Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Reviews

Biological Activity for Ro 3306

Ro 3306 is an ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (Ki values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (Ki values are 0.89-1.32, 0.03 and >2 μM for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).

Compound Libraries for Ro 3306

Ro 3306 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Ro 3306

M. Wt 351.45
Formula C18H13N3OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 872573-93-8
PubChem ID 11631681
InChI Key XOLMRFUGOINFDQ-YBEGLDIGSA-N
Smiles O=C2/C(SC(NCC3=CC=CS3)=N2)=C/C1=CC=C(N=CC=C4)C4=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 3306

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.03 20 with gentle warming

Preparing Stock Solutions for Ro 3306

The following data is based on the product molecular weight 351.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.23 mL 71.13 mL 142.27 mL
1 mM 2.85 mL 14.23 mL 28.45 mL
2 mM 1.42 mL 7.11 mL 14.23 mL
10 mM 0.28 mL 1.42 mL 2.85 mL

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Product Datasheets for Ro 3306

Certificate of Analysis / Product Datasheet
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References for Ro 3306

References are publications that support the biological activity of the product.

Kojima et al (2009) The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 100 1128 PMID: 19385969

Vassilev et al (2006) Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc.Natl.Acad.Sci. 103 10660 PMID: 16818887

Yu et al (2012) CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage. Cancer Res. 72 5448 PMID: 22962268

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987


If you know of a relevant reference for Ro 3306, please let us know.

View Related Products by Product Action

View all CDK1 Subfamily Inhibitors

Keywords: Ro 3306, Ro 3306 supplier, Ro3306, inhibits, cdk1, cyclin-dependent, kinase, 1, inhibitors, cell, cycle, arrest, apoptotic, Cyclin-dependent, Kinase, CDK1, Subfamily, 4181, Tocris Bioscience

10 Citations for Ro 3306

Citations are publications that use Tocris products. Selected citations for Ro 3306 include:

Sacristan et al (2018) Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nat Cell Biol 20 800 PMID: 29915359

Smith et al (2019) PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. Cell Rep 28 2206 PMID: 31433993

Liccardi et al (2019) RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell 73 413 PMID: 30598363

Ramkumar et al (2015) JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1. J Biol Chem 290 29617 PMID: 26468278


Do you know of a great paper that uses Ro 3306 from Tocris? Please let us know.

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